ERG (NM_182918) Human Untagged Clone
SKU
SC108516
ERG (untagged)-Human v-ets erythroblastosis virus E26 oncogene homolog (avian) (ERG), transcript variant 1
$457.00
In Stock*
Specifications
| Product Data | |
| Type | Human Untagged Clone |
|---|---|
| Target Symbol | ERG |
| Synonyms | erg-3; p55 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data | |
| Restriction Sites | NotI-NotI | |
| ACCN | NM_182918 |
| Insert Size | 3000 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_182918.2, NP_891548.1 |
| RefSeq Size | 3055 bp |
| RefSeq ORF | 1440 bp |
| Locus ID | 2078 |
| UniProt ID | P11308 |
| Cytogenetics | 21q22.2 |
| Protein Families | Druggable Genome, Transcription Factors |
| Summary | This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. More than two dozens of transcript variants generated from combinatorial usage of three alternative promoters and multiple alternative splicing events have been reported, but the full-length nature of many of these variants has not been determined. provided by RefSeq, Apr 2014 Transcript Variant: This variant (1) contains a different segment for its 5' UTR and 5' coding region, compared to variant 3. The resulting protein (isoform 1) has a shorter and distinct N-terminus when it is compared to isoform 3. Sequence Note: The RefSeq transcript and protein were derived from transcript and genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_182918" in other vectors (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC208093 | ERG (Myc-DDK-tagged)-Human v-ets erythroblastosis virus E26 oncogene homolog (avian) (ERG), transcript variant 1 | 10 ug |
$457.00
|
|
| RC208093L1 | Lenti ORF clone of Human v-ets erythroblastosis virus E26 oncogene homolog (avian) (ERG), transcript variant 1, Myc-DDK-tagged | 10 ug |
$757.00
|
|
| RC208093L2 | Lenti ORF clone of Human v-ets erythroblastosis virus E26 oncogene homolog (avian) (ERG), transcript variant 1, mGFP tagged | 10 ug |
$757.00
|
|
| RC208093L3 | Lenti ORF clone of Human v-ets erythroblastosis virus E26 oncogene homolog (avian) (ERG), transcript variant 1, Myc-DDK-tagged | 10 ug |
$757.00
|
|
| RC208093L4 | Lenti ORF clone of Human v-ets erythroblastosis virus E26 oncogene homolog (avian) (ERG), transcript variant 1, mGFP tagged | 10 ug |
$757.00
|
|
| RG208093 | ERG (tGFP-tagged) - Human v-ets erythroblastosis virus E26 oncogene homolog (avian) (ERG), transcript variant 1 | 10 ug |
$489.00
$657.00
|
|
Citations
FZD4 as a mediator of ERG oncogene-induced WNT signaling and epithelial-to-mesenchymal transition in human prostate cancer cells
Gupta, Iljin, Sara et al
Cancer Res (2010) 70 (17), 6735-45 DOI: 10.1158/0008-5472.CAN-10-0244
Gupta, Iljin, Sara et al
Cancer Res (2010) 70 (17), 6735-45 DOI: 10.1158/0008-5472.CAN-10-0244
AI Summary: OriGene products contributed to this study by providing the FZD4 cDNA clone and FZD4 shRNA constructs, which were used for FZD4 overexpression and silencing experiments to investigate its role in ERG-mediated WNT signaling and epithelial-to-mesenchymal transition in prostate cancer cells.
Showing 1-2 of 2 papers.
Powered by BizGenius
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
Related Products
- Price:
- Actual Price:
Welcome to OriGene AI!
I'm your AI-powered guide to everything OriGene.
Ask me anything:
- Product specs
- Ordering help
- Technical questions
- How to find exactly what your experiment needs
Prefer a live agent? Connect with us by clicking the green chat icon, as seen in the image below or email our team at custsupport@origene.com.
