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GRK6 (NM_002082) Human Untagged Clone

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SKU
SC108487
GRK6 (untagged)-Human G protein-coupled receptor kinase 6 (GRK6), transcript variant 2
  $824.00
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Specifications
Specifications
Product Data
Type Human Untagged Clone
Target Symbol GRK6
Synonyms GPRK6
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Restriction Sites NotI-NotI |
ACCN NM_002082
Insert Size 2880 bp
OTI Disclaimer Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.

The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_002082.2, NP_002073.2
RefSeq Size 2932 bp
RefSeq ORF 1770 bp
Locus ID 2870
UniProt ID P43250
Cytogenetics 5q35.3
Domains pkinase, RGS, S_TKc, S_TK_X, TyrKc
Protein Families Druggable Genome, Protein Kinase
Protein Pathways Chemokine signaling pathway, Endocytosis
Summary This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described for this gene. provided by RefSeq, Jul 2008
Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (B).
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Documents
Resources
"NM_002082" in other vectors (7)
SKU Description Size Price
RC218924 GRK6 (Myc-DDK-tagged)-Human G protein-coupled receptor kinase 6 (GRK6), transcript variant 2 10 ug
$225.00
RC218924L1 Lenti ORF clone of Human G protein-coupled receptor kinase 6 (GRK6), transcript variant 2, Myc-DDK-tagged 10 ug
$525.00
RC218924L2 Lenti ORF clone of Human G protein-coupled receptor kinase 6 (GRK6), transcript variant 2, mGFP tagged 10 ug
$525.00
RC218924L3 Lenti ORF clone of Human G protein-coupled receptor kinase 6 (GRK6), transcript variant 2, Myc-DDK-tagged 10 ug
$525.00
RC218924L4 Lenti ORF clone of Human G protein-coupled receptor kinase 6 (GRK6), transcript variant 2, mGFP tagged 10 ug
$525.00
RG218924 GRK6 (tGFP-tagged) - Human G protein-coupled receptor kinase 6 (GRK6), transcript variant 2 10 ug
$425.00
SC323679 GRK6 (untagged)-Kinase deficient mutant (K215M) of Human G protein-coupled receptor kinase 6 (GRK6), transcript variant 2 10 ug
$824.00

file-alt Citations

Chemerin-activated functions of CMKLR1 are regulated by G protein-coupled receptor kinase 6 (GRK6) and β-arrestin 2 in inflammatory macrophages
Serafin, Allyn, Sassano et al
Mol. Immunol. (2018) 106, 12-21 DOI: 10.1016/j.molimm.2018.12.016
AI Summary: OriGene products, specifically the pCMV6-XL5 GRK2, pCMV6-XL5 GRK3, pCMV6-XL5 GRK5, pCMV6-XL5 GRK6 transcript 1 plasmids, and pCMV6-XL5 vector, were used for over-expression studies to investigate the regulatory roles of different GRKs in CMKLR1 signaling in inflammatory macrophages.
Snippet: The following plasmids were used for GRK over-expression as obtained from Origene (Rockville, MD, USA): pCMV6-XL5 GRK2, pCMV6-XL5 GRK3, pCMV6-XL5 GRK5, pCMV6-XL5 GRK6 transcript 1, and pCMV6-XL5 vector as a negative control
Showing 1-1 of 1 papers.
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