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IRF5 (NM_032643) Human Untagged Clone

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SKU
SC104269
IRF5 (untagged)-Human interferon regulatory factor 5 (IRF5), transcript variant 2
  $457.00
5 Days*
Bulk Requests & Clone Modifications

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Specifications
Specifications
Product Data
Type Human Untagged Clone
Target Symbol IRF5
Synonyms SLEB10
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
Fully Sequenced ORF
>OriGene ORF within SC104269 sequence for NM_032643 edited (data generated by NextGen Sequencing)
ATGAACCAGTCCATCCCAGTGGCTCCCACCCCACCCCGCCGCGTGCGGCTGAAGCCCTGG
CTGGTGGCCCAGGTGAACAGCTGCCAGTACCCAGGGCTTCAATGGGTCAACGGGGAAAAG
AAATTATTCTGCATCCCCTGGAGGCATGCCACAAGGCATGGTCCCAGCCAGGACGGAGAT
AACACCATCTTCAAGGCCTGGGCCAAGGAGACAGGGAAATACACCGAAGGCGTGGATGAA
GCCGATCCGGCCAAGTGGAAGGCCAACCTGCGCTGTGCCCTTAACAAGAGCCGGGACTTC
CGCCTCATCTACGACGGGCCCCGGGACATGCCACCTCAGCCCTACAAGATCTACGAGGTC
TGCTCCAATGGCCCTGCTCCCACAGACTCCCAGCCCCCTGAGGATTACTCTTTTGGTGCA
GGAGAGGAGGAGGAAGAAGAGGAAGAGCTGCAGAGGATGTTGCCAAGCCTGAGCCTCACA
GAGGATGTCAAGTGGCCGCCTACTCTGCAGCCGCCCACTCTGCRGCCGCCTACTCTGCAG
CCGCCCACTCTGCAGCCGCCCGTGGTGCTGGGTCCCCCTGCTCCAGACCCCAGCCCCCTG
GCTCCTCCCCCTGGCAACCCTGCTGGCTTCAGGGAGCTTCTCTCTGAGGTCCTGGAGCCT
GGGCCCCTGCCTGCCAGCCTGCCCCCTGCAGGCGAACAGCTCCTGCCAGACCTGCTGATC
AGCCCCCACATGCTGCCTCTGACCGACCTGGAGATCAAGTTTCAGTACCGGGGGCGGCCA
CCCCGGGCCCTCACCATCAGCAACCCCCATGGCTGCCGGCTCTTCTACAGCCAGCTGGAG
GCCACCCAGGAGCAGGTGGAACTCTTCGGCCCCATAAGCCTGGAGCAAGTGCGCTTCCCC
AGCCCTGAGGACATCCCCAGTGACAAGCAGCGCTTCTACACGAACCAGCTGCTGGATGTC
CTGGACCGCGGGCTCATCCTCCAGCTACAGGGCCAGGACCTTTATGCCATCCGCCTGTGT
CAGTGCAAGGTGTTCTGGAGCGGGCCTTGTGCCTCAGCCCATGACTCATGCCCCAACCCC
ATCCAGCGGGAGGTCAAGACCAAGCTTTTCAGCCTGGAGCATTTTCTCAATGAGCTCATC
CTGTTCCAAAAGGGCCAGACCAACACCCCACCACCCTTCGAGATCTTCTTCTGCTTTGGG
GAAGAATGGCCTGACCGCAAACCCCGAGAGAAGAAGCTCATTACTGTACAGGTGGTGCCT
GTAGCAGCTCGACTGCTGCTGGAGATGTTCTCAGGGGAGCTATCTTGGTCAGCTGATAGT
ATCCGGCTACAGATCTCAAACCCAGACCTCAAAGACCGCATGGTGGAGCAATTCAAGGAG
CTCCATCACATCTGGCAGTCCCAGCAGCGGTTGCAGCCTGTGGCCCAGGCCCCTCCTGGA
GCAGGCCTTGGTGTTGGCCAGGGGCCCTGGCCTATGCACCCAGCTGGCATGCAATAA

Clone variation with respect to NM_032643.3
501 c=>t;524 g=>r
5' Read Nucleotide Sequence
>OriGene 5' read for NM_032643 unedited
GGATTTTGTAATACGACTCACTATAGGGCGGCCGCGAATTCGGCACGAGGGTGCTCCCTG
GCGCAGCCACGCAGGCGCACCGCAGACAGACCCCTCTGCCATGAACCAGTCCATCCCAGT
GGCTCCCACCCCACCCCGCCGCGTGCGGCTGAAGCCCTGGCTGGTGGCCCAGGTGAACAG
CTGCCAGTACCCAGGGCTTCAATGGGTCAACGGGGAAAAGAAATTATTCTGCATCCCCTG
GAGGCATGCCACAAGGCATGGTCCCAGCCAGGACGGAGATAACACCATCTTCAAGGCCTG
GGCCAAGGAGACAGGGAAATACACCGAAGGCGTGGATGAAGCCGATCCGGCCAAGTGGAA
GGCCAACCTGCGCTGTGCCCTTAACAAGAGCCGGGACTTCCGCCTCATCTACGACGGGCC
CCGGGACATGCCACCTCAGCCCTACAAGATCTACGAGGTCTGCTCCAATGGCCCTGCTCC
CACAGACTCCCAGCCCCCTGAGGATTACTCTTTTGGTGCAGGAGAGGAGGAGGAAGAAGA
GGAAGAGCTGCAGAGGATGTTGCCAAGCCTGAGCCTCACAGAGGATGTCAAGTGGCCGCC
CACTCTGCAGCCGCCCACTCTGCGGCCGCCTACTCTGCAGCCGCCCACTCTGCAGCCGCC
CCGTGGTGCTGGGGTCCCCCNTGCTCCAGACCCCAGCCCCCTGGCTCCTCCCCCTGGCAA
CCCTGCTGGCTTCAGGGAGCTTCTCTTCTGAGTCCTGGAGCCTGNGCCCCTGCCTGCCAG
CCTGCCCCCTGCANGCGAACAGCTCCTGCCAGACCTGCTGATCAGCCCCCCATGCTGNCT
CTGACGANCTGGAGNACAAGNTTCAGTACCGGGGGCGGNCACCCCGGGCCTCACATCAGC
ACCCCCATGGTGNCGCTCTCTCANCAGCTGGAGCACCAGAACAGGTGGACTCTTCGCCCA
TAGCTGGAGCAGGCN
3' Read Nucleotide Sequence
>OriGene 3' read for NM_032643 unedited
CCCGCATTCTAGAGTCGAGTTTTTTTTTTTTTTTTTTAATTTATACAGGAAAAGGTTTAT
TTGGCTCACAGTTCTGATGGCTGGGCATCAAGATTGGGCATCTGCACCTGGTAAGGGCCT
GGGGCAGCTTCCACTCAATGGCTGAAGGCAGAAAGTGGGCTGGAGTGTGCAGAGATGACA
CAGATGAAGTGAGAGCGGGTAGGTGCCAGGCTCTTTAACAACCAGCTCTGGGGGGACTAA
GAGAACTCACTCACTGTCCCCACCTCGGGGGACAATATAATAAATATATTAAATATATCA
GGATGATTTACATGCACTGCCCTGATATATTTAATAGCACAGGAATATACACAAGAGAGT
GACAGATTTGAATGGTCCCAAATGCAGCTGCAATGCTAGCCCACCCTTTTATGGGAAAAC
TGATTCTGACAGTTTTCCAGACTGTGCACACATTTAAAATTCCACACCCTTGCTTCAGCC
AGCTTCCTCCTGGAAGGCAAAGCCAGCCAGGTGAGTGTTTATGAAGGCCCAACTGACCCA
TCAGCCCAGAAGCCAGGCCCTCCCAGTGCCAATGGTCGCAAGCTGAGCGCAAGTGCTTGG
GGAGCGGGCCAGTTGGCATCCGAAACAGGGCCTGGTGGAGCAGCATGCGAGCAACTGGTA
GTAGTATAAGGGAAAGAACAAGCTGAGCCTGTTCTCTACATTCATTATTCGCAAAAATAC
ATAANAAATCTATTTCTGCCTCCAGGCTCTTGGACTCTCAGGAAAGGCGGTAGCTGCCAG
CCCTCGAGCATCTGATTTGATACCCTAGCGCCTCACTCATTTTATTCTCAGAAGACACGG
CAGATGAGGCAGCGGAGTCTCACACCAAGGGAATTACGCCCATGCCCTGCATAGCGCTCG
GGGGGGGACTTGGTCACACCACTCTGTCTTTTGTTGCACAAGGAATGGGCATTCCAAAAG
TCGCCACCTTAGCATTCCTCTATCACTAGCCCCAGGTGGAGAT
Restriction Sites NotI-NotI |
ACCN NM_032643
Insert Size 2770 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_032643.3, NP_116032.1
RefSeq Size 2771 bp
RefSeq ORF 1497 bp
Locus ID 3663
UniProt ID Q13568
Cytogenetics 7q32.1
Domains IRF
Protein Families Transcription Factors
Protein Pathways Toll-like receptor signaling pathway
Summary This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Alternative promoter use and alternative splicing result in multiple transcript variants, and a 30-nt indel polymorphism (SNP rs60344245) can result in loss of a 10-aa segment. provided by RefSeq, Dec 2016
Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site, compared to variant 9. The encoded isoform (b) is shorter, compared to isoform d. Variants 2, 3, and 6 encode the same isoform.
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Documents
Resources
"NM_032643" in other vectors (6)
SKU Description Size Price
RC200458 IRF5 (Myc-DDK-tagged)-Human interferon regulatory factor 5 (IRF5), transcript variant 2 10 ug
$457.00
RC200458L1 Lenti ORF clone of Human interferon regulatory factor 5 (IRF5), transcript variant 2, Myc-DDK-tagged 10 ug
$757.00
RC200458L2 Lenti ORF clone of Human interferon regulatory factor 5 (IRF5), transcript variant 2, mGFP tagged 10 ug
$757.00
RC200458L3 Lenti ORF clone of Human interferon regulatory factor 5 (IRF5), transcript variant 2, Myc-DDK-tagged 10 ug
$757.00
RC200458L4 Lenti ORF clone of Human interferon regulatory factor 5 (IRF5), transcript variant 2, mGFP tagged 10 ug
$757.00
RG200458 IRF5 (tGFP-tagged) - Human interferon regulatory factor 5 (IRF5), transcript variant 2 10 ug
$489.00 $657.00

file-alt Citations

Intermittent hypoxia-reoxygenation-induced miRNAs inhibit expression of IRF and interferon genes but activate NF-κB and expression of pulmonary fibrosis markers in human small airway epithelial cells
Chen, Jheng, Lee et al
Life Sci (2025) 370, 123569 DOI: 10.1016/j.lfs.2025.123569
Cited by 2
AI Summary: OriGene products, specifically the cDNA clones with catalogue numbers SC212811, SC104269, SC125442, SC215826, and SC307967, were used as PCR templates to generate constructs for luciferase reporter assays to investigate miRNA targeting of specific genes in this study.
Snippet: y amplified by PCR from the cDNA clones with the catalogue numbers SC212811, SC104269, SC125442, SC215826, and SC307967, which were purchased from OriGene Technologies, and subcloned into the psiCHECK -2 vector (Promega Product No. C8021) downstr
A TNIP1-driven systemic autoimmune disorder with elevated IgG4
Medhavy, Athanasopoulos, Bassett et al
Nat Immunol (2024)
Cited by 14
AI Summary: OriGene products, specifically the untagged TBK1 (cat. no. SC11125) and untagged IRF5 (cat. no. SC104269) expression vectors, were used in this study to investigate the molecular mechanisms underlying TNIP1-driven systemic autoimmune disorder with elevated IgG4.
Snippet: The following expression vectors were obtained: untagged TBK1 (cat. no. SC11125, Origene Technologies);HA-TNIP1 (cat. no. HG14942-NY, Sino Biological);untagged IRF5 (cat. no. SC104269, OriGene Technologies), untagged MyD88 (cat. no. OHu21475, GenScript)
Functional rare and low frequency variants in BLK and BANK1 contribute to human lupus
Jiang, Athanasopoulos, Ellyard et al
Nat Commun (2019) 10 (1), 2201 DOI: 10.1038/s41467-019-10242-9
AI Summary: OriGene products, specifically the untagged BLK and untagged IRF5 expression vectors, were used in this study to investigate the functional impact of rare and low-frequency variants in BLK and BANK1 on lupus risk.
Snippet: …Expression vectors and mutagenesis The following expression vectors were obtained: untagged BLK (OriGene Technologies), myc-LYN (GeneCopoeia, Inc.), untagged IRF5 (OriGene Technologies). …Expression vectors and mutagenesis The following expression vectors were obtained: untagged BLK (OriGene Technologies), myc-LYN (GeneCopoeia, Inc.), untagged IRF5 (OriGene Technologies). …
FigureFigureFigure
Rotavirus NSP1 inhibits expression of type I interferon by antagonizing the function of interferon regulatory factors IRF3, IRF5, and IRF7
Barro, Patton
J Virol (2007) 81 (9), 4473-81 DOI: 10.1128/JVI.02498-06
AI Summary: In this study, OriGene products—specifically, the IRF3, IRF5, and IRF7 expression plasmids—were used to investigate how rotavirus NSP1 induces the degradation of these interferon regulatory factors, thereby elucidating NSP1’s role in suppressing type I interferon expression.
FigureFigureFigure
Showing 1-4 of 4 papers.
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