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EZH2 (NM_152998) Human Untagged Clone

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SKU
SC101257
EZH2 (untagged)-Human enhancer of zeste homolog 2 (Drosophila) (EZH2), transcript variant 2
  $648.00
In Stock*
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Specifications
Specifications
Product Data
Type Human Untagged Clone
Target Symbol EZH2
Synonyms ENX-1; ENX1; EZH2b; KMT6; KMT6A; WVS; WVS2
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
Fully Sequenced ORF
>OriGene ORF within SC101257 sequence for NM_152998 edited (data generated by NextGen Sequencing)
ATGGGCCAGACTGGGAAGAAATCTGAGAAGGGACCAGTTTGTTGGCGGAAGCGTGTAAAA
TCAGAGTACATGCGACTGAGACAGCTCAAGAGGTTCAGACGAGCTGATGAAGTAAAGAGT
ATGTTTAGTTCCAATCGTCAGAAAATTTTGGAAAGAACGGAAATCTTAAACCAAGAATGG
AAACAGCGAAGGATACAGCCTGTGCACATCCTGACTTCTGTGAGCTCATTGCGCGGGACT
AGGGAGGTGGAAGATGAAACTGTTTTACATAACATTCCTTATATGGGAGATGAAGTTTTA
GATCAGGATGGTACTTTCATTGAAGAACTAATAAAAAATTATGATGGGAAAGTACACGGG
GATAGAGAATGTGGGTTTATAAATGATGAAATTTTTGTGGAGTTGGTGAATGCCCTTGGT
CAATATAATGATGATGACGATGATGATGATGGAGACGATCCTGAAGAAAGAGAAGAAAAG
CAGAAAGATCTGGAGGATCACCGAGATGATAAAGAAAGCCGCCCACCTCGGAAATTTCCT
TCTGATAAAATTTTTGAAGCCATTTCCTCAATGTTTCCAGATAAGGGCACAGCAGAAGAA
CTAAAGGAAAAATATAAAGAACTCACCGAACAGCAGCTCCCAGGCGCACTTCCTCCTGAA
TGTACCCCCAACATAGATGGACCAAATGCTAAATCTGTTCAGAGAGAGCAAAGCTTACAC
TCCTTTCATACGCTTTTCTGTAGGCGATGTTTTAAATATGACTGCTTCCTACATCCTTTT
CATGCAACACCCAACACTTATAAGCGGAAGAACACAGAAACAGCTCTAGACAACAAACCT
TGTGGACCACAGTGTTACCAGCATTTGGAGGGAGCAAAGGAGTTTGCTGCTGCTCTCACC
GCTGAGCGGATAAAGACCCCACCAAAACGTCCAGGAGGCCGCAGAAGAGGACGGCTTCCC
AATAACAGTAGCAGGCCCAGCACCCCCACCATTAATGTGCTGGAATCAAAGGATACAGAC
AGTGATAGGGAAGCAGGGACTGAAACGGGGGGAGAGAACAATGATAAAGAAGAAGAAGAG
AAGAAAGATGAAACTTCGAGCTCCTCTGAAGCAAATTCTCGGTGTCAAACACCAATAAAG
ATGAAGCCAAATATTGAACCTCCTGAGAATGTGGAGTGGAGTGGTGCTGAAGCCTCAATG
TTTAGAGTCCTCATTGGCACTTACTATGACAATTTCTGTGCCATTGCTAGGTTAATTGGG
ACCAAAACATGTAGACAGGTGTATGAGTTTAGAGTCAAAGAATCTAGCATCATAGCTCCA
GCTCCCGCTGAGGATGTGGATACTCCTCCAAGGAAAAAGAAGAGGAAACACCGGTTGTGG
GCTGCACACTGCAGAAAGATACAGCTGAAAAAGGACGGCTCCTCTAACCATGTTTACAAC
TATCAACCCTGTGATCATCCACGGCAGCCTTGTGACAGTTCGTGCCCTTGTGTGATAGCA
CAAAATTTTTGTGAAAAGTTTTGTCAATGTAGTTCAGAGTGTCAAAACCGCTTTCCGGGA
TGCCGCTGCAAAGCACAGTGCAACACCAAGCAGTGCCCGTGCTACCTGGCTGTCCGAGAG
TGTGACCCTGACCTCTGTCTTACTTGTGGAGCCGCTGACCATTGGGACAGTAAAAATGTG
TCCTGCAAGAACTGCAGTATTCAGCGGGGCTCCAAAAAGCATCTATTGCTGGCACCATCT
GACGTGGCAGGCTGGGGGATTTTTATCAAAGATCCTGTGCAGAAAAATGAATTCATCTCA
GAATACTGTGGAGAGATTATTTCTCAAGATGAAGCTGACAGAAGAGGGAAAGTGTATGAT
AAATACATGTGCAGCTTTCTGTTCAACTTGAACAATGATTTTGTGGTGGATGCAACCCGC
AAGGGTAACAAAATTCGTTTTGCAAATCATTCGGTAAATCCAAACTGCTATGCAAAAGTT
ATGATGGTTAACGGTGATCACAGGATAGGTATTTTTGCCAAGAGAGCCATCCAGACTGGC
GAAGAGCTGTTTTTTGATTACAGATACAGCCAGGCTGATGCCCTGAAGTATGTCGGCATC
GAAAGAGAAATGGAAATCCCTTGA

Clone variation with respect to NM_152998.2
5' Read Nucleotide Sequence
>OriGene 5' read for NM_152998 unedited
CCCCGGGTGCGGATTTATGTATACGATCTCACTATAGGGCGGCCGCGAATTCGCACGAGG
GTCCGACACCCGGTGGGACTCATAAGGCAGTGGAGCCCCGGCGGCGGCGGCGGCGGCGCG
CGGGGGCGACGCGCGGGAACAACGCGAGTCGGCGCGCGGGACGAAGAATAATCATGGGCC
AGACTGGGAAGAAATCTGAGAAGGGACCAGTTTGTTGGCGGAAGCGTGTAAAATCAGAGT
ACATGCGACTGAGACAGCTCAAGAGGTTCAGACGAGCTGATGAAGTAAAGAGTATGTTTA
GTTCCAATCGTCAGAAAATTTTGGAAAGAACGGAAATCTTAAACCAAGAATGGAAACAGC
GAAGGATACAGCCTGTGCACATCCTGACTTCTGTGAGCTCATTGCGCGGGACTAGGGAGG
TGGAAGATGAAACTGTTTTACATAACATTCCTTATATGGGAGATGAAGTTTTAGATCAGG
ATGGTACTTTCATTGAAGAACTAATAAAAAATTATGATGGGAAAGTACACGGGGATAGAG
AATGTGGGTTTATAAATGATGAAATTTTTGTGGAGTTGGTGAATGCCCTTGGTCAATATA
ATGATGATGACGATGATGATGATGGAGACGATCCTGAAGAAAGAGAAGAAAAGCAGAAAG
ATCTGGAGGATCACCGAGATGATAAAGAAAGCCGCCCACCTCGGAAATTTCCTTCTGATA
AAATTTTTGAAGCCATTTCCTCAATGGTTCCAGATNAGGGCACAGCAGAAGAACTAAAGG
GAAAATATAAAGAACTCACCCGACAGCAGCTCCCAGGCGCACTTNCTTNNCTGATGTACC
CCACATAGATGGACCAAATGCTAAATCTGTTCAGAGAGAGCAAAGCTTACACTNCTNTCA
TACGCTTTTCTGTAGA
3' Read Nucleotide Sequence
>OriGene 3' read for NM_152998 unedited
NGGACTCGGGATGGCACTCCCCGTTCCAGGATAGCACTGAGGCAGGGTCACAGGGCTGCC
ACCCGGGTTCTGTTCAGGAAACAGCTATGACCGCGGCCGCAATCTATAGTCGAGTTTTTT
TTTTTTTTTTTTGACAAGTTCAAGTTTTCTTTATTCAAAGTTGAAAAATGTACCATACTG
CATTATTGCAAAAATTCACTGGTACAAAACACTTTGCTTCTGGTGAGAAGGCAATAAAAA
GTTGATTTTTAAACTCATTACTATAAATTATTCTTACAGTACTTTGCAAATTCAGAATTT
CAAACTGCATGTTCTTTTTCTAAATTGCCCACAGTACTCGAGGTTCCTGAAGCTAAGGCA
GCTGTTTCAGAGGAGGGGGGAAGAGGTAGCAGATGTCAAGGGATTTCCATTTCTCTTTCG
ATGCCGACATACTTCAGGGCATCAGCCTGGCTGTATCTGTAATCAAAAAACAGCTCTTCG
CCAGTCTGGATGGCTCTCTTGGCAAAAATACCTATCCTGTGATCACCGTTAACCATCATA
ACTTTTGCATAGCAGTTTGGATTTACCGAATGATTTGCAAAACGAATTTTGTTACCCTTG
CGGGTTGCATCCACCACAAAATCATTGTTCAAGTTGAACAGAAAGCTGCACATGTATTTA
TCATACACTTTCCCTCTTCTGTCAGCTTCATCTTGAGAAATAATCTCTCCACAGTATTCT
GAGATGAATTCATTTTTCTGCACAGGATCTTTGATAAAAATCCCCCAGCCTGCCACGTCA
GATGGTGCCCAGCATATATGCTTTTTGGAGCCCACGCTGATACTGCAGTTCTTGCAGGAA
CATTTTTACTGTCCCAATGGTCAGCGGCTTCACAGTAAGACAGAGGTCAGGGTCACACTC
TCGGACN
Restriction Sites NotI-NotI |
ACCN NM_152998
Insert Size 2600 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_152998.1, NP_694543.1
RefSeq Size 2563 bp
RefSeq ORF 2124 bp
Locus ID 2146
UniProt ID Q15910
Cytogenetics 7q36.1
Domains DnaJ, myb_DNA-binding, SET
Protein Families Druggable Genome, Transcription Factors
Summary This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene. provided by RefSeq, Feb 2011
Transcript Variant: This variant (2) lacks an in-frame exon and an in-frame segment in the coding region, as compared to variant 1. The resulting isoform (b) lacks two internal segments, as compared to isoform a.
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Documents
Resources
"NM_152998" in other vectors (6)
SKU Description Size Price
RC216079 EZH2 (Myc-DDK-tagged)-Human enhancer of zeste homolog 2 (Drosophila) (EZH2), transcript variant 2 10 ug
$647.00
RC216079L1 Lenti ORF clone of Human enhancer of zeste homolog 2 (Drosophila) (EZH2), transcript variant 2, Myc-DDK-tagged 10 ug
$947.00
RC216079L2 Lenti ORF clone of Human enhancer of zeste homolog 2 (Drosophila) (EZH2), transcript variant 2, mGFP tagged 10 ug
$947.00
RC216079L3 Lenti ORF clone of Human enhancer of zeste homolog 2 (Drosophila) (EZH2), transcript variant 2, Myc-DDK-tagged 10 ug
$947.00
RC216079L4 Lenti ORF clone of Human enhancer of zeste homolog 2 (Drosophila) (EZH2), transcript variant 2, mGFP tagged 10 ug
$947.00
RG216079 EZH2 (tGFP-tagged) - Human enhancer of zeste homolog 2 (Drosophila) (EZH2), transcript variant 2 10 ug
$789.00 $847.00

file-alt Citations

Effects of miR‑195‑5p on cell proliferation and apoptosis in gestational diabetes mellitus via targeting EZH2
Liao, Zhou, Zhang
Mol Med Rep (2020) 22 (2), 803-809 DOI: 10.3892/mmr.2020.11142
Cited by 22
AI Summary: OriGene products, specifically the EZH2 overexpression plasmid (Cat# RC217747) and control plasmid (Cat# PS100001), were used in this study to assess the effects of EZH2 upregulation on cell proliferation and apoptosis in gestational diabetes mellitus-induced HUVECs.
FigureFigureFigure
Effects of miR‑195‑5p on cell proliferation and apoptosis in gestational diabetes mellitus via targeting EZH2
Liao, Zhou, Zhang
Mol Med Report (2020)
Cited by 22
AI Summary: OriGene products contributed to this study by providing the pCMV6‑XL5‑EZH2 plasmid (cat. no. SC101257) used for cell transfection experiments to investigate the role of EZH2 in gestational diabetes mellitus.
Snippet: BD Biosciences) in the dark. Cell transfection. pCMV6‑XL5‑EZH2 (cat. no. SC101257) and its empty control vector were purchased from OriGene Technologies, Inc. miR‑195‑5p mimics (cat. no. miR10000461‑1‑5, 5'‑CGG UUA
Showing 1-2 of 2 papers.
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