Mtmr9 (NM_177594) Mouse Untagged Clone

SKU MC203249

Mtmr9 (untagged) - Mouse myotubularin related protein 9 (Mtmr9), (10ug)

Product Data

• Type: Mouse Untagged Clone
• Target Symbol: Mtmr9
• Synonyms: 9430075G12Rik; AA516943; AF073881; LIP-STYX; mMTMH3; MTMR8
• Vector: PCMV6-Kan/Neo
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >BC046275; CCCTGGCTGCTCGGGCTCGGATGCTGCTGCCCCGACGCCGGGTCCGTCTCCTCCGCAGCCCGCCCGTCAG ACGCCGGTGGCAGCGGGGAGTGCAGGGCCTGGCGGGAAGCCTTCTCTGCGACCGAGTCCCGGCCAGTGGT GCGGAAGAGACTTGGAGAAGCGGCCAGGGCGGTGCCCGCAGGCCCTGGCGCACCCGCCCAGCCGGGGCGG GGCTCGACCTCCCGGGCCCGCCCAGCCGGGGCTCCGTCCGGGTCTGCGGATTAACCGCCGGGCACCTGCG GGACTGGGCCTCCCGCCCCTAGGCTGCGCCCAATATGGAGTTTGCGGAGCTGATTAAAACCCCACGGGTA GACAATGTGGTGCTGCACCGGCCTTTCTACACCGCCGTGGAAGGGACCCTGTGTCTGACAGGCCACCACC TGATCCTGTCTTCCCGGCAGGACAACACGGAGGAGCTCTGGCTCCTCCATTCAAATATCGACGCCATCGA CAAACGATTTGTGGGCTCTCTGGGTACCATCATCATAAAATGTAAAGATTTCCGAATCATTCAGTTGGAT ATTCCTGGAATGGAGGAGTGTTTAAATATAGCCAGTTCCATTGAGGCATTGTCCACTCTGGACTCGGTCA CCCTGATGTACCCTTTCTTCTACCGACCCATGTTTGAAGTGATTGAAGATGGCTGGCATTCTTTCCTTCC TGAGCAAGAATTTGAGTTCTACTCTTCTGCTACCAGTGAATGGAGACTGAGCTATATCAATAAGGACTTT TCTATCTGTCCTTCCTACCCACCAACTGTCATTGTGCCCAAGTCCGTCGATGACGAAGCACTTCGGAAGG TAGCAGCCTTCCGACATGGGGGGCGCTTCCCAGTCCTGAGCTATTACCATAAAAAGAATGGCATGGTGAT TATGCGAAGTGGTCAGCCCCTGACCGGCACAAACGGGAGGAGGTGCAAGGAAGACGAGAAGCTGATAAAT GCCACCCTCAGGGCAGGAAAGCGTGGCTACCTTATTGACACCAGATCCCTAAATGTGGCCCAGCAAGCTA GAGCCAAAGGAGGTGGCTTTGAACAGGAGGCTCATTATCCCCAGTGGAGGCGGATTCACAAGTCCATTGA GAGATACCATGTTCTTCAGGAGAGCCTAATCAAACTCGTGGAAGCATGTAATGAACAAACCCACAACATG GACCGGTGGCTCGGCAAGTTGGAGGCCTCCAATTGGCTGACACACATCAAGGAGATTCTGACCACCGCCT GCCTGGCGGCCCAGTGCATTGACAGGGAAGGTGCATCAGTGTTGATTCATGGGACAGAAGGAACTGATTC CACACTGCAGGTGACTTCTCTGGCCCAGATCATCCTGGAACCAAGAAGCAGGACCATCCGAGGCTTTGAG GCCCTGATAGAGAGGGAGTGGCTGCAGGCTGGTCACCCATTCCAACAGCGCTGTGCACAGTCAGCCTATT GCAGCAGCAAGCAGAAGTGGGAGGCCCCCGTGTTTCTTCTCTTCCTGGACTGCGTGTGGCAGATCCTCCG GCAGTTCCCTTGCTCCTTCGAGTTTAATGAGCATTTTCTCATCATGCTCTTTGAGCATGCTTATGCCTCA CAGTTCGGGACATTCCTGGGCAACAATGAAAGTGAAAGATGTAAGTTGAAGCTACAACAGAAAACAATGT CTTTGTGGTCATGGGTCAATCGGCCCGGCGAGCTGAGTAAGTTCACCAATCCACTCTTTGAAGCCAACAA CCTGGTCATCTGGCCTTCTGTGGCGCCACAGAGTCTTCAGCTGTGGGAAGGAATCTTCTTACGCTGGAGC AGATCCTCCAAGTATCTGGATGAAGCATATGAGGAAATGGTTAACATCATTGAATATAACAAGGAGTTAC AAGCCAAGGTCAATGTCCTGAGAAGGCAGTTGGCTGAATTGGAAACAGAGGATGGGCTATGAGAGAGTCC TTGAAAGATCGCCTACCTGTCCTGAGGACCTGTCTAGTCCTGAGTCGTCTCTCCCTCTGTTTGCCCTTCA ATTCATGTTCACAGTAGCCTTGAACTTGGCTGTAGGTGCGGAATCCCTGTAATGTAATGGCCTTCTAAGC ACTGCAAGGTGGCAGTCACTCACAGATATGGCCTGTTAGGCCCTCCACTTAATGAGCAGGTGGTGCTGTC ACCTCACTACATATATGACACCTATGCCCTATGCTGTTCCCCATCTCTAGTTTCTCACCAGTGGTCCAGA CTAGTTAAGAATCCATCTACAACATGGGCCAGGCTTATTTGCATTCGAGTATAGAGGTGTTTCTTTTTTT AATGGAAATAATTGGGAAGCCACAATTGTATGTTTAACATGTCATCCTGCCCCTATCCTCCACTCCCAGT TATAAAAAGACCATTCTTTTTTAAAACAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAA
• Restriction Sites: RsrII-NotI
• ACCN: NM_177594
• Insert Size: 1638 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution Method: 1. Centrifuge at 5,000xg for 5min.; 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.; 3. Close the tube and incubate for 10 minutes at room temperature.; 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.; 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
• Note: Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required.
• Shipping: Ambient

Reference Data

• RefSeq: BC046275, AAH46275
• RefSeq Size: 2457 bp
• RefSeq ORF: 1638 bp
• Locus ID: 210376
• UniProt ID: Q9Z2D0
• Cytogenetics: 14 D1
• Summary: Acts as an adapter for myotubularin-related phosphatases (PubMed:12890864). Increases lipid phosphatase MTMR6 catalytic activity, specifically towards phosphatidylinositol 3,5-bisphosphate, and MTMR6 binding affinity for phosphorylated phosphatidylinositols (By similarity). Positively regulates lipid phosphatase MTMR7 catalytic activity (PubMed:12890864). The formation of the MTMR6-MTMR9 complex, stabilizes both MTMR6 and MTMR9 protein levels (By similarity). Plays a role in the late stages of macropinocytosis possibly by regulating MTMR6-mediated dephosphorylation of phosphatidylinositol 3-phosphate in membrane ruffles (By similarity). Negatively regulates DNA damage-induced apoptosis, in part via its association with MTMR6 (By similarity). Does not bind mono-, di- and tri-phosphorylated phosphatidylinositols, phosphatidic acid and phosphatidylserine (By similarity).[UniProtKB/Swiss-Prot Function]