Fermt2 (NM_146054) Mouse Untagged Clone
$624.00
In Stock*
Specifications
| Product Data | |
| Type | Mouse Untagged Clone |
|---|---|
| Target Symbol | Fermt2 |
| Synonyms | AA960555; Kindlin-2; Mig2; Plekhc1 |
| Vector | PCMV6-Kan/Neo |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data | |
| Restriction Sites | RsrII-NotI | |
| ACCN | NM_146054 |
| Insert Size | 2043 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | BC033436, AAH33436 |
| RefSeq Size | 3197 bp |
| RefSeq ORF | 2043 bp |
| Locus ID | 218952 |
| UniProt ID | Q8CIB5 |
| Cytogenetics | 14 C1 |
| Summary | Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling.UniProtKB/Swiss-Prot Function |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_146054" in other vectors (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| MG209996 | Fermt2 (tGFP-tagged) - Mouse pleckstrin homology domain containing, family C (with FERM domain) member 1 (Plekhc1) | 10 ug |
$824.00
|
|
| MR209996 | Fermt2 (Myc-DDK-tagged) - Mouse fermitin family homolog 2 (Drosophila) (Fermt2) | 10 ug |
$589.00
$624.00
|
|
| MR209996L3 | Lenti ORF clone of Fermt2 (Myc-DDK-tagged) - Mouse fermitin family homolog 2 (Drosophila) (Fermt2) | 10 ug |
$924.00
|
|
| MR209996L4 | Lenti ORF clone of Fermt2 (mGFP-tagged) - Mouse fermitin family homolog 2 (Drosophila) (Fermt2) | 10 ug |
$924.00
|
|
Citations
A defective mechanosensing pathway affects fibroblast-to-myofibroblast transition in the old male mouse heart
Angelini, Trial, Saltzman et al
iScience (2023) 26 (8), 107283 DOI: 10.1016/j.isci.2023.107283
Angelini, Trial, Saltzman et al
iScience (2023) 26 (8), 107283 DOI: 10.1016/j.isci.2023.107283
Cited by 12
AI Summary: OriGene products, including Fermt2 Mouse siRNA Oligo duplexes (SR419055), Trilencer-27 Universal Scrambled Negative Control siRNA Duplex (SR30005), and Fermt2 Mouse Untagged clone plasmid (MC202155), were used to manipulate Kindlin-2 expression in cardiac fibroblasts, enabling the study of its role in mechanosensing and fibroblast-to-myofibroblast transition in aging male mouse hearts.
Snippet: C57bl6/J mice old male and old female (24–30 months old) National Institute of Aging ------------------------- Oligonucleotides ------------------------- Fermt2 Mouse siRNA Oligo duplexes Origene SR419055 Trilencer-27 Universal Scrambled Negative Control siRNA Duplex Origene SR30005 Fermt2 Mouse Untagged clone plasmid Origene MC202155 PCMV6-Kan/Neo Untagged Cloning Vec
Showing 1-1 of 1 papers.
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