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IRF8 (NM_002163) Human 3' UTR Clone

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SKU
SC214035
3' UTR clone of interferon regulatory factor 8 (IRF8) for miRNA target validation
  $683.00
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Specifications
Specifications
Product Data
Vector pMirTarget
Species Human
Transfection Reporter RFP
Assay Reporter Luciferase
E. coli Selection Kanamycin (25 ug/mL)
Mammalian Cell Selection Neomycin
Target Symbol IRF8
Synonyms H-ICSBP; ICSBP; ICSBP1; IMD32A; IMD32B; IRF-8
ACCN NM_002163
Insert Size 1315 bp
Sequence Data
Insert Sequence
>SC214035 3' UTR clone of NM_002163
The sequence shown below is from the reference sequence of NM_002163. The complete sequence of this clone may contain minor differences, such as SNPs. Red=Cloning site Blue=Stop Codon


CAATTGGCAGAGCTCAGAATTCAAGCGATCGC

CCAACAGATCACCGTCTAAGTGCGTCGCTTGGGCGCCCCACCCCGTCTGCGTCCTGCATCCATCTCCCTG
TTACAGTGGCCCGCATCATGATTAAAGAATGTGGATCCCTCTGTCTGGGGTGGGATGCCTTACTTTGCAC
TTAATTTAATAAGGGCATTCTCGGAGGAGTAGACGTTTAATACGAAGTGGCGGCATAGCCCTGCCGAGAT
GTCGGTGATGGCCTGGATGCTGTAACCACAACCTGTGGCTAAAAATTTTATTTTCTATCCTTTACCCGTC
ATTATCATTAGTTGCTATGATTCTTTCTGCATTTTCGGTTAACTATCATTTCCAAAGACTTGTCATTCAG
TAATATTAGCAGATAGCTGCTTCGATAAAGGAATTTGGAGTTTAAAAATCAACTTGTGAAAACAAGGTTG
TTTTTGTCTTTATCGTTTGTTAGAGTTATAGATTTATGATTTCATAGGCTTGATTCTATGTGAAATATCT
TTTTACTTTTATGCATTTTAATAAGATTTAAAAATATTTAGATTAAAGCCCCCTTTAATGAGTACAAGAA
AAACTCTTGGCTTGTTAGAAGAAAGTATATTCTTTCTAGAATTTGGTGCAGGAATATGTGTTCATATCCA
GGCAAACGGGTGTGTTTTTATCTTCAGACAATGAAACCTTCTCCTCTGGGGCTTTGTTGCCAGGAAGATT
AGAACTAAATTTATTTTTTTCATTTCTGTCATGAAATCATTCCAGATACCTCTTTTCTTCTTTCCAAATG
GTTTTCACATGTGTTTGAAATATTTGTACTTCGAATTGTCGGATTTTCCATGTCCTCCTTTCTCCTTTGT
GCCCAGCCTGAGTCAGCACCAATCCCGCATTCAGAACCTCCCAGTGAAAGGGCAGCCTTCATTTTGAGAA
GGTGGAAGGTGTTAGGGTTTGGGAGACAGCTCATCCAATCTCCCAAGTCTCATGGTGGATTTGTGACTGT
GAGAGTTTCCGGTTTAAAATCTGAAAAGCCAGATATGCCTGTTTCCTTTTCCCAGCACCATGCCTGTGGA
GGGGACAGTCAGACCCAGAGGTCCTTTACGTGTGGATGGAGTTCACAGGCGAATAGAGGAGAGGACCAGG
GGACGTGGCTTGTCCCTTTTGTCCAACAAAGCATTATATTTTTAAGAATGGCAGACCTGTTTGCTGAAGT
GTTCATAAGATAACAATAGGCTTGAATCTCCAATTCAAATGAATGTCAAAGCACATATCTTTAATATGCT
GAATGAATATTTATTTTTGTATCCATTAAAACAGTATATTGATCTCTTTTATTCT

ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCG
Restriction Sites SgfI-MluI |
OTI Disclaimer Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as 10 ug dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_002163.2
Locus ID 3394
Summary Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection. provided by RefSeq, Jul 2008
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Documents
Resources

file-alt Citations

MicroRNA-1270 Inhibits Cell Proliferation, Migration, and Invasion via Targeting IRF8 in Osteoblast-like Cell Lines
Ramírez-Salazar, Almeraya, López-Perez et al
Curr Issues Mol Biol (2022) 44 (3), 1182-1190 DOI: 10.3390/cimb44030077
Cited by 15
AI Summary: OriGene products, specifically the IRF8 Human cDNA ORF Clone (RC212230) and IRF8-specific siRNA (SR321274), were used in this study to manipulate IRF8 expression and elucidate the regulatory effects of miR-1270 on osteoblast-like cell proliferation, migration, and invasion.
FigureFigureFigure
MicroRNA-1270 Inhibits Cell Proliferation, Migration, and Invasion via Targeting IRF8 in Osteoblast-like Cell Lines
Ramírez-Salazar, Almeraya, López-Perez et al
CIMB (2022) 44 (3), 1182-1190 DOI: 10.3390/cimb44030077
Cited by 15
AI Summary: OriGene’s pMir-Target-IRF8_3′-UTR wt plasmid (cat. no. SC214035) was used in luciferase assays to demonstrate that miR-1270 directly targets the 3′-UTR of IRF8, thereby elucidating the molecular mechanism by which miR-1270 regulates IRF8 expression in osteoblast-like cells.
Snippet: …The pMir-Target plasmid encompassing the human wild-type (wt) IRF8 3′-untranslated region (pMir-Target-IRF8_3′-UTR wt) was purchased from OriGene Technologies, Inc., Rockville, MD, USA (cat. … SC214035). The mutated version of the binding sequence of miR-1270 on IRF8 3′-UTR (pMir-Target-IRF8_3′-UTR mut) was generated using the Qui;The pMir-Target plasmid encompassing the human wildtype (wt) IRF8 30 -untranslated region (pMir-Target-IRF8_30 -UTR wt) was purchased from OriGene Technologies, Inc.,
Showing 1-2 of 2 papers.
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