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Human GDF-15 ELISA Kit

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SKU
EA100484
Human GDF-15 ELISA Kit
  $755.00
3 Weeks*
Specifications
Specifications
Product Data
Species Human
Assay Type Sandwich ELISA kit of Quantitative Detection for Human GDF-15
Assay Length 3.5 hours incubations; 1 hour washing and analyzing samples
Signal Colorimetric
Curve Range 31.2pg/ml-2000pg/ml
Sample Type Cell culture supernates, serum and plasma(heparin, EDTA).
Sample Volume 100 ul
Specificity This kit is used for quantitative detection of human GDF-15
Sensitivity <10pg/ml
Reactivity Human
Cross Reactivity There is no detectable cross-reactivity with other relevant proteins.
Interference No significant interference observed with available related molecules.
Components
  • 96-well plate precoated with anti- human GDF-15 antibody 1
  • Lyophilized recombinant human GDF-15 standard 10ng/tubex2
  • Biotinylated anti- human GDF-15 antibody 130ul(dilution 1:100)
  • Avidin-Biotin-Peroxidase Complex(ABC) 130ul(dilution 1:100)
  • Sample diluent buffer 30ml
  • Antibody diluent buffer 12ml
  • ABC diluent buffer 12ml
  • TMB color developing agent 10ml
  • TMB stop solution 10ml
Background GDF-15(Growth differentiation factor 15),also known as TGF-PL, MIC-1, PDF, PLAB, and PTGFB, is a protein belonging to the transforming growth factor beta superfamily that has a role in regulating inflammatory and apoptotic pathways in injured tissues and during disease processes. Using FISH, the MIC1 gene is mapped to 19p13.2-p13.1. Its expression in liver can be significantly up-regulated in during injury of organs such as liver, kidney, heart and lung. GDF15 showed increased expression and secretion during erythroblast maturation. GDF15 functions as an antiinflammatory cytokine by directly interfering with chemokine signaling and integrin activation.
Gene Symbol GDF15
Locus ID 9518
Shipping Blue Ice
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Documents
Resources

file-alt Citations

GDF-15 negatively regulates excess erythropoiesis and its overexpression is involved in erythroid hyperplasia
Ranjbaran, Abbasi, Rahimian et al
Exp Cell Res (2020) 397 (2), 112346 DOI: 10.1016/j.yexcr.2020.112346
Cited by 17
AI Summary: In this study, OriGene's GDF-15 recombinant protein (Cat# TP721718) was used to treat hematopoietic stem cells in vitro, enabling the researchers to assess the direct effects of elevated GDF-15 on erythroid colony formation and differentiation.
Association between Growth Differentiation Factor 15 and Cardiovascular Risk in Patients with Type 2 Diabetes Mellitus
El-Shafae, Issa, Abdel moneam et al
Benha Medical Journal (2020)
Snippet: CHD ( Coronary Heart Disease) Risk Framingham [10] and GDF 15 was measured using a quantitative sandwich enzyme linked immunosorbent assay [11] using (ELISA) kit (OriGene Technologies, Rockville, MD;USA, Catalog No. EA100484) and performed on (BioTek;- CHD ( Coronary Heart Disease) Risk Framingham [10] and GDF 15 was measured using a quantitative sandwich enzyme linked immunosorbent assay [11] using (ELISA) kit (OriGene Technologies, Rockville, MD
Analysis of GDF15 and IGFBP7 in Hyperemesis Gravidarum Support Causality
Fejzo, Fasching, Schneider et al
Geburtshilfe Frauenheilkd (2019) 79 (4), 382-388 DOI: 10.1055/a-0830-1346
Cited by 74
AI Summary: OriGene products, specifically the Human GDF15 ELISA Kit (EA100819) and Human IGFBP7 ELISA Kit (EA100922), were used in this study to measure serum levels of GDF15 and IGFBP7, helping to demonstrate their significant upregulation in women with hyperemesis gravidarum compared to controls.
FigureFigureFigure
Association between Growth Differentiation Factor 15 (GDF15) and Cardiovascular Risk in Patients with Newly Diagnosed Type 2 Diabetes Mellitus
Shin, Kim, Kang et al
J Korean Med Sci (2016) 31 (9), 1413-8 DOI: 10.3346/jkms.2016.31.9.1413
Cited by 66
AI Summary: OriGene’s Human GDF15 ELISA Kit (EA100819) was used to measure serum GDF15 levels, enabling the authors to assess the association between GDF15 and cardiovascular risk in newly diagnosed type 2 diabetes patients.
Figure
Showing 1-4 of 4 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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