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Human Survivin ELISA Kit

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SKU
EA100414
Human Survivin ELISA Kit
  $755.00
3 Weeks*
Specifications
Specifications
Product Data
Species Human
Assay Type Sandwich ELISA kit of Quantitative Detection for Human Survivin
Assay Length 3.5 hours incubations; 1 hour washing and analyzing samples
Signal Colorimetric
Curve Range 62.5pg/ml-4000pg/ml
Sample Type Cell culture supernates, serum and plasma(heparin, EDTA).
Sample Volume 100 ul
Specificity This kit is used for quantitative detection of human Survivin
Sensitivity <2pg/ml
Reactivity Human
Cross Reactivity There is no detectable cross-reactivity with other relevant proteins.
Interference No significant interference observed with available related molecules.
Components
  • 96-well plate precoated with anti- human Survivin antibody 1
  • Lyophilized recombinant human Survivin standard 4ng/tubex2
  • Biotinylated anti- human Survivin antibody 130ul(dilution 1:100)
  • Avidin-Biotin-Peroxidase Complex(ABC) 130ul(dilution 1:100)
  • Sample diluent buffer 30ml
  • Antibody diluent buffer 12ml
  • ABC diluent buffer 12ml
  • TMB color developing agent 10ml
  • TMB stop solution 10ml
Background Survivin(also termed API4) belongs to the family of genes known as inhibitors of apoptosis, and it has been implicated in both prevention of cell death and control of mitosis. Survivin is prominently expressed in transformed cell lines and in all the most common human cancers of lung, colon, pancreas, prostate and breast in vivo. It is also found in approximately 50% of high-grade non-Hodgkin's lymphomas. Survivin encodes a deduced 142-amino acid protein and localizes on chromosome 17q25. The overexpression of it in cancer may overcome an apoptotic checkpoint and favour aberrant progression of transformed cells through mitosis. The standard product used in this kit is recombinant human Survivin with the molecular mass of 34 KDa.
Gene Symbol BIRC5
Locus ID 332
Shipping Blue Ice
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Documents
Resources

file-alt Citations

Dysregulation of microRNAs regulating survivin in CD4+ T cells in multiple sclerosis
Alizadeh-Fanalou, Alian, Mohammadhosayni et al
Mult Scler Relat Disord (2020) 44, 102303 DOI: 10.1016/j.msard.2020.102303
Cited by 15
AI Summary: OriGene’s Human Survivin ELISA Kit was used in this study to measure serum survivin levels, enabling the assessment of its expression in multiple sclerosis patients compared to healthy controls.
Snippet: Applying the enzyme-linked immunosorbent assay (ELISA) and a commercial Human Survivin ELISA Kit (OriGene Technologies, Inc., Rockville, MD, USA), the serum level of survivin was measured. Experiments were conducted in triplicate order. 2.7. Statistical analysis;Applying the enzyme-linked immunosorbent assay (ELISA) and a commercial Human Survivin ELISA Kit (OriGene Technologies, Inc., Rockville, ...
Genetic polymorphisms and epigenetic regulation of survivin encoding gene, BIRC5, in multiple sclerosis patients
Rahban, Mohammadi, Alidadi et al
BMC Immunol. (2019) 20 (1), 30 DOI: 10.1186/s12865-019-0312-1
AI Summary: OriGene's Human Survivin ELISA Kit was used in this study to measure serum survivin levels in multiple sclerosis patients and controls, enabling the assessment of survivin's role in disease risk and regulation.
Snippet: solated from the peripheral blood of 50 patients and 50 control subjects. Survivin level was determined using enzyme-linked immunosorbent assay (ELISA) and a commercial kit (Human Survivin ELISA Kit, OriGene Technologies, Inc., Rockville, MD, USA). STATISTICAL ANALYSIS Genotype and allelic distribution between case and control groups were implemented by Chi-Square test. Pearson’s χ2-tests wer;.....
FigureFigureFigure
AMPK/mTOR-Mediated Inhibition of Survivin Partly Contributes to Metformin-Induced Apoptosis in Human Gastric Cancer Cell
Han, Gong, Wang et al
Cancer Biol. Ther. (2014)
Cited by 107
AI Summary: In this study, OriGene’s survivin overexpression plasmid (RC208445) and survivin siRNA (SR321835) were used to manipulate survivin expression in gastric cancer cells, helping to demonstrate that AMPK/mTOR-mediated inhibition of survivin partly contributes to metformin-induced apoptosis.
Snippet: Cite SaveSaving
Showing 1-3 of 3 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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