Human uPA/PLAU ELISA Kit
$755.00
3 Weeks*
| Product Data | |
| Species | Human |
|---|---|
| Assay Type | Sandwich ELISA kit of Quantitative Detection for Human uPA/PLAU |
| Assay Length | 3.5 hours incubations; 1 hour washing and analyzing samples |
| Signal | Colorimetric |
| Curve Range | 62.5pg/ml-4000pg/ml |
| Sample Type | Cell culture supernates, serum and plasma(heparin, EDTA). |
| Sample Volume | 100 ul |
| Specificity | This kit is used for quantitative detection of human uPA |
| Sensitivity | <5pg/ml |
| Reactivity | Human |
| Cross Reactivity | There is no detectable cross-reactivity with other relevant proteins. |
| Interference | No significant interference observed with available related molecules. |
| Components |
|
| Background | Plasminogen activator,urokinase(PLAU, uPA) converts plasminogen to plasmin. Plasmin is involved in processing of amyloid precursor protein and degrades secreted and aggregated amyloid-beta, a hallmark of Alzheimer disease(AD). Urokinase has a molecular mass of about 54 kD and is composed of 2 disulfide-linked chains, A and B, of molecular masses 18 kD and 33 kD, respectively. It localized on 10q24. uPA facilitates cell migration by localizing proteolisys on the cell surface and by inducing intracellular signalling pathways. In human vascular smooth muscle cell(VSMC), uPA stimulates migration via the uPA receptor(uPAR) signalling complex containing TYK2 and phosphatidylinositol 3-kinase(PI3-K). |
| Gene Symbol | PLAU |
| Locus ID | 5328 |
| Shipping | Blue Ice |
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| Datasheet | |
| SDS | |
Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.