OriGene Logo

Customer Login

Checkout as a new customer

Creating an account has many benefits:

  • See order and shipping status
  • Track order history
  • Check out faster
Create an Account

Human TIMP-3 ELISA Kit

Be the first to review this product
SKU
EA100363
Human TIMP-3 ELISA Kit
  $755.00
3 Weeks*
Specifications
Specifications
Product Data
Species Human
Assay Type Sandwich ELISA kit of Quantitative Detection for Human TIMP-3
Assay Length 3.5 hours incubations; 1 hour washing and analyzing samples
Signal Colorimetric
Curve Range 156pg/ml-10,000pg/ml
Sample Type Cell culture supernates, serum, plasma(heparin , EDTA) and saliva.
Sample Volume 100 ul
Specificity This kit is used for quantitative detection of human TIMP-3
Sensitivity <2pg/ml
Reactivity Human
Cross Reactivity There is no detectable cross-reactivity with other relevant proteins.
Interference No significant interference observed with available related molecules.
Components
  • 96-well plate precoated with anti- human TIMP-3 antibody 1
  • Lyophilized recombinant human TIMP-3 standard 10ng/tubex2
  • Biotinylated anti- human TIMP-3 antibody 130ul(dilution 1:100)
  • Avidin-Biotin-Peroxidase Complex(ABC) 130ul(dilution 1:100)
  • Sample diluent buffer 30ml
  • Antibody diluent buffer 12ml
  • ABC diluent buffer 12ml
  • TMB color developing agent 10ml
  • TMB stop solution 10ml
Background The tissue inhibitors of metalloproteinases(TIMPs) are natural inhibitors of the matrix metalloproteinases, a group of zinc-binding endopeptidases involved in the degradation of the extracellular matrix. The TIMP3 gene is expressed in many tissues, with highest expression in the placenta. TIMP3 encodes a potent angiogenesis inhibitor and is mutated in Sorsby fundus dystrophy, a macular degenerative disease with submacular choroidal neovascularization. TIMP3 gene is mapped to 22q12.1-q13.2. Mutations in TIMP3 cause the autosomal dominant disorder Sorsby's fundus dystrophy(SFD).
Gene Symbol TIMP3
Locus ID 7078
Shipping Blue Ice
Reviews
Write Review
 
 
 
 
 

Be the first to review this product

Please note:
Only reviews with images are eligible for a $20/20€ Amazon gift card.
Reviews without images are eligible for a $10/10€ Amazon gift card.
For more details about the terms and conditions, please visit the promotion page.

Review image
Documents
Resources

file-alt Citations

Increased pro-MMP9 plasma levels are associated with neovascular age-related macular degeneration and with the risk allele of rs142450006 near MMP9
Lauwen, Lefeber, Fauser et al
Mol Vis (2021) 27, 142-150
AI Summary: OriGene’s Human TIMP-3 ELISA Kit (Cat. Nr: EA100363) was used to quantify plasma TIMP3 levels in the study, enabling comparison between neovascular age-related macular degeneration patients and controls.
Snippet: TIMP3 levels were quantified using the Human TIMP-3 ELISA Kit (Cat. Nr: {"type":"entrez-nucleotide","attrs":{"text":"EA100363","term_id":"145032279","term_text":" EA100363"}}EA100363;OriGene Technologies Inc., Rockville, MD);- TIMP3 levels were quantified using the Human TIMP-3 ELISA Kit (Cat. Nr: {"type":"entrez-nucleotide","attrs":{"text":"EA100363","term_id":"145032279","term_text":" EA100363"}}EA100363
FigureFigureFigure
Showing 1-1 of 1 papers.
Powered by BizGenius
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

Related Products