IGHG4 Mouse Monoclonal Antibody [Clone ID: HP6025]
$485.00
5 Days*
Specifications
| Product Data | |
| Clone Name | HP6025 |
|---|---|
| Application | ELISA, FC, IF, IHC, IP, WB |
| Recommended Dilution | ELISA: 1/1000-1/2000 (2-9). Immunohistochemistry on Frozen Sections: reported in literature (5,7,10,11). Immunohistochemistry on Paraffin Sections: reported in literature (10). Flow Cytometry: reported in literature (15, 18, 19). Immunocytochemistry: reported in literature (12). Western Blot: reported in literature (3,13-16). |
| Reactivity | Human |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | Human IgG4 myeloma protein |
| Specificity | This Monoclonal HP6025 antibody recognizes the heavy chain of Human IgG4, at an epitope in the Fc region. No cross-reactivity is observed with IgG1, IgG2, IgG3, IgM, IgA. Cross reactivity with immunoglobulins from other species has not been tested. |
| Buffer | 50mM Tris/ 1 mM MgCl2, 50 % Glycerol, pH 8.0 Label: AP State: Purified State: Liquid purified IgG fraction Preservative: 0.09% Sodium Azide Label: Alkaline Phosphatase |
| Presentation State | Purified |
| Concentration | lot specific |
| Conjugation | AP |
| Storage | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
| Shipping | Blue Ice |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Citations
IgG4 glycosylation contributes to the pathogenesis of IgG4 Hashimoto's thyroiditis via the complement pathway
Zhao, Sun, Wang et al
Eur Thyroid J (2024)
Zhao, Sun, Wang et al
Eur Thyroid J (2024)
AI Summary: OriGene's anti-human IgG4 antibody (HP6025) was used in this study to detect and analyze IgG4 localization and deposition in thyroid tissues and mouse models, contributing to the investigation of IgG4's role in Hashimoto's thyroiditis pathogenesis.
Snippet: mary antibodies used were anti-TPO (1:5000, ab278525, Abcam, UK), anti-human IgG4 (1:500, HP6025, Origene, USA), anti-MAC (1:500, bs-2673R, Bioss, China), and anti-CD45 (1:5000, ab208
Determinants of C1q binding in the single antigen bead assay
Schaub, Hönger, Koller et al
Transplantation (2014) 98 (4), 387-93 DOI: 10.1097/TP.0000000000000203
Schaub, Hönger, Koller et al
Transplantation (2014) 98 (4), 387-93 DOI: 10.1097/TP.0000000000000203
AI Summary: In this study, OriGene’s anti-human globulin (AHG) was used to enhance the C1q single antigen bead (SAB) assay signal, enabling the researchers to assess how AHG affects the detection of complement-binding antibodies.
Pretransplant IgG reactivity to apoptotic cells correlates with late kidney allograft loss
Gao, Moore, Porcheray et al
Am J Transplant (2014) 14 (7), 1581-91 DOI: 10.1111/ajt.12763
Gao, Moore, Porcheray et al
Am J Transplant (2014) 14 (7), 1581-91 DOI: 10.1111/ajt.12763
Cited by 55
AI Summary: In this study, OriGene’s anti-human IgG1 (cat# TA500113) and anti-human IgG3 (cat# TA500115) antibodies were used to characterize the IgG subclasses mediating serum reactivity to apoptotic cells, helping to demonstrate that pretransplant IgG1 and IgG3 responses correlate with increased risk of late kidney allograft loss.
Donor-specific HLA antibodies: evaluating the risk for graft loss in renal transplant recipients with isotype switch from complement fixing IgG1/IgG3 to noncomplement fixing IgG2/IgG4 anti-HLA alloantibodies
Arnold, Ntokou, Doxiadis et al
Transpl Int (2014) 27 (3), 253-61 DOI: 10.1111/tri.12206
Arnold, Ntokou, Doxiadis et al
Transpl Int (2014) 27 (3), 253-61 DOI: 10.1111/tri.12206
Cited by 51
AI Summary: In this study, OriGene products—specifically anti-human IgG2 (TA500272), anti-human IgG4 (TA500275), anti-human IgA1 (TA500276), and anti-human IgA2 (TA500277) antibodies—were used to detect and characterize HLA antibody subclasses in patient samples, enabling the assessment of their association with renal graft outcomes.
Significant IgG subclass heterogeneity in HLA-specific antibodies: Implications for pathogenicity, prognosis, and the rejection response
Lowe, Higgins, Zehnder et al
Hum Immunol (2013) 74 (5), 666-72 DOI: 10.1016/j.humimm.2013.01.008
Lowe, Higgins, Zehnder et al
Hum Immunol (2013) 74 (5), 666-72 DOI: 10.1016/j.humimm.2013.01.008
Cited by 62
AI Summary: In this study, OriGene's anti-human IgG subclass-specific antibodies (catalog numbers: TA500062, TA500063, TA500064, and TA500065) were used to detect and analyze the distribution of HLA-specific IgG subclasses in sensitized patients, enabling the authors to characterize subclass heterogeneity relevant to transplant rejection.
Pathogen-triggered activation of plasmacytoid dendritic cells induces IL-10-producing B cells in response to Staphylococcus aureus
Parcina, Miranda-Garcia, Durlanik et al
J Immunol (2013) 190 (4), 1591-602 DOI: 10.4049/jimmunol.1201222
Parcina, Miranda-Garcia, Durlanik et al
J Immunol (2013) 190 (4), 1591-602 DOI: 10.4049/jimmunol.1201222
Cited by 52
AI Summary: In this study, OriGene’s anti-TLR9 antibody (Cat# TA303598) was used to detect TLR9 expression, contributing to the investigation of TLR9 involvement in plasmacytoid dendritic cell activation and B cell proliferation in response to Staphylococcus aureus.
Showing 1-6 of 14 papers.
Powered by BizGenius
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
Related Products
- Price:
- Actual Price:
Welcome to OriGene AI!
I'm your AI-powered guide to everything OriGene.
Ask me anything:
- Product specs
- Ordering help
- Technical questions
- How to find exactly what your experiment needs
Prefer a live agent? Connect with us by clicking the green chat icon, as seen in the image below or email our team at custsupport@origene.com.
