LGR5 Mouse Monoclonal Antibody [Clone ID: UMAB212]
Specifications
| Product Data | |
| Clone Name | UMAB212 |
|---|---|
| Application | 10k-ChIP, FC, IF, IHC, WB |
| Recommended Dilution | WB 1:1000~2000, IHC 1:100~150 (recommended antigen retrieval buffer: TEE buffer pH 9.0), IF 1:100, FLOW 1:100 |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Mouse |
| Isotype | IgG2a |
| Clonality | Monoclonal |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 22-543 of human LGR5 (NP_003658) produced in HEK293 cell. |
| Buffer | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide |
| Concentration | 0.5~1.0 mg/ml (Lot Dependent) |
| Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | 99.8 kDa |
| Gene Name | leucine rich repeat containing G protein-coupled receptor 5 |
| Database Link | |
| Synonyms | FEX; GPR49; GPR67; GRP49; HG38 |
| Reference Data | |
| Protein Categories | GPCR, Membrane Proteins |
| Protein Families | Druggable Genome, GPCR, Transmembrane |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other "UMAB212" antibodies (3)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| UM800104CF | Carrier-free (BSA/glycerol-free) LGR5 mouse monoclonal antibody,clone UMAB212 | 100 ug |
$680.00
|
|
| UM800104HM | LGR5 mouse monoclonal antibody, Clone UMAB212, PE conjugated (50 tests) | 100 ul |
$610.00
|
|
| UM870104 | LGR5 mouse monoclonal antibody,clone UMAB212 | 30 ul |
$224.00
|
|
Citations
Comprehensive investigation of milk-derived extracellular vesicles on intestinal stem cell-based models
Wang, Zeng, Wang et al
J Dairy Sci (2026)
Wang, Zeng, Wang et al
J Dairy Sci (2026)
Comparative studies on the components and anti-ulcerative colitis effects of raw and carbonized Linderae Radix
Zheng, Li, Hu et al
J Ethnopharmacol (2025) 355 (Pt A), 120629 DOI: 10.1016/j.jep.2025.120629
Zheng, Li, Hu et al
J Ethnopharmacol (2025) 355 (Pt A), 120629 DOI: 10.1016/j.jep.2025.120629
Cited by 3
Colonic epithelial-derived FGF1 drives intestinal stem cell commitment toward goblet cells to suppress inflammatory bowel disease
Lin, Zhang, Zhang et al
Nat Commun (2025) 16 (1), 3264 DOI: 10.1038/s41467-025-58644-2
Lin, Zhang, Zhang et al
Nat Commun (2025) 16 (1), 3264 DOI: 10.1038/s41467-025-58644-2
Cited by 22
AI Summary: In this study, the OriGene product Lgr5 antibody (UM870104) was used to identify intestinal stem cells, aiding in the investigation of how epithelial-derived FGF1 influences stem cell differentiation and suppresses inflammatory bowel disease.
Snippet: , sc-393941, Santa Cruz Biotechnology), Fabp1 (1:50, CST13368, Cell Signaling Technology), Ki67 (1:400, ab15580, Abcam), FGFR2 (1:200, CST23328S, Cell Signaling Technology) and Lgr5 (1:100, UM870104, ORIGENE). After washing the slides with PBS, the sections were incubated with anti-rabbit IgG Fab2 Alexa Fluor 488 (1:400, ab150073, Abcam), anti-mouse IgG Fab2 Alexa Fluor 647 (1:400, ab150105, A
Enhancing precision in colorectal cancer surgery: development of an LGR5-targeting RSPO1 peptide mimetic as a contrast agent for intraoperative fluorescence molecular imaging
Parasido, Ribeiro, Chingle et al
Cell Cycle (2024)
Parasido, Ribeiro, Chingle et al
Cell Cycle (2024)
Cited by 1
AI Summary: OriGene contributed to this study by providing the LGR5 primary antibody (OriGene #UM800104CF), which was used to detect LGR5 expression in cells during the validation of the RSPO1-mimetic peptide contrast agent for colorectal cancer imaging.
Snippet: Next, the cells were incubated with primary antibodies against LGR5 (Origene #UM800104CF) or myc-tag (Cell Signaling #2276) at the dilutions recommended by the
The Hippo Pathway Effector YAP1 Regulates Intestinal Epithelial Cell Differentiation
Fallah, Beaulieu
Cells (2020) 9 (8) DOI: 10.3390/cells9081895
Fallah, Beaulieu
Cells (2020) 9 (8) DOI: 10.3390/cells9081895
Cited by 25
AI Summary: In this study, OriGene’s mouse monoclonal anti-LGR5 antibody (UMAB212) was used to detect LGR5 expression by Western blot and immunofluorescence, helping to assess the effects of YAP1 knockdown on intestinal stem cell markers.
Snippet: monoclonal anti-YAP/TAZ (D24E4, 1/1500 WB, 1/50 IF, Cell Signaling, Danvers, MA, USA), mouse monoclonal anti-CDX2-CD88 (MU392A-UC, 1/700, BioGenex, Freemont, CA, USA), mouse monoclonal anti-LGR5 (UMAB212, 1/100 WB and 1/100 IF, Origene, Rockville Cached
Showing 1-6 of 7 papers.
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