SHP2 (PTPN11) Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | WB |
|---|---|
| Recommended Dilution | WB: 1:500~2000 |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | Recombinant protein of human PTPN11 |
| Buffer | PBS (pH 7.3) containing 50% glycerol and 0.02% sodium azide |
| Concentration | 2.23 mg/ml |
| Purification | Purified from the immunized serum by affinity chromatography (Protein A/G) |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | 67.8 kDa |
| Gene Name | protein tyrosine phosphatase, non-receptor type 11 |
| Database Link | |
| Background | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. provided by RefSeq, Aug 2016 |
| Synonyms | BPTP3; CFC; JMML; METCDS; NS1; PTP-1D; PTP2C; SH-PTP2; SH-PTP3; SHP2 |
| Reference Data | |
| Protein Categories | Cancer: Haematopoietic and Lymphoid, Cytokines, Growth Factors, Intracellular Proteins |
| Protein Families | Druggable Genome, Phosphatase |
| Protein Pathways | Adipocytokine signaling pathway, Chronic myeloid leukemia, Epithelial cell signaling in Helicobacter pylori infection, Jak-STAT signaling pathway, Leukocyte transendothelial migration, Natural killer cell mediated cytotoxicity, Neurotrophin signaling pathway, Renal cell carcinoma |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other antibodies (1)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| TA890142 | Rabbit Polyclonal anti-PTPN11 Antibody | 100 ul |
$407.00
|
|
Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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