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ASK1 (MAP3K5) Rabbit Polyclonal Antibody

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SKU
TA890021
Rabbit polyclonal anti-MAP3K5 Antibody
Size:
100 ul 30 ul
Conjugation:
Unconjugated
  $407.00
In Stock*
Bulk/Customize

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View other "ASK1 or NM_005923" antibodies

Specifications
Specifications
Product Data
Application WB
Recommended Dilution WB: 1:500~1:1000
Reactivity Human, Mouse, Rat
Antibody Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Recombinant protein of human MAP3K5
Buffer PBS (pH 7.3) containing 50% glycerol and 0.02% sodium azide
Concentration 1.18mg/ml
Purification Purified from the immunized serum by affinity chromatography (Protein A/G)
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Blue Ice
Predicted Protein Size 154.4 kDa
Gene Name mitogen-activated protein kinase kinase kinase 5
Database Link
Background Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK. provided by RefSeq, Jul 2008
Synonyms ASK1; MAPKKK5; MEKK5
Reference Data
Protein Categories Enzyme: Kinases, Intracellular Proteins
Protein Families Druggable Genome, Protein Kinase
Protein Pathways Amyotrophic lateral sclerosis (ALS), MAPK signaling pathway, Neurotrophin signaling pathway
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Documents
Resources
Other antibodies (1)
SKU Description Size Price
TA890021S Rabbit polyclonal anti-MAP3K5 Antibody 30 ul
$188.00

file-alt Citations

The Elevated ASK1 Expression Inhibits Proliferation and Invasion in Gastric Cancer HGC-27 Cells
Wan, Shi, Ma et al
Anat Rec (Hoboken) (2018)
AI Summary: OriGene contributed mouse anti-human monoclonal antibodies against ASK1, p-p38, p38, p-JNK, JNK, p-ERK, ERK, and GAPDH, which were used in Western blot experiments to analyze signaling protein expression in the study.
Snippet: min. The primary antibodies (mouse anti- human monoclonal antibody ASK1/p-p38/p38/p-JNK/JNK p-ERK/ERK/GAPDH, ORIGENE) were added into block- ing solution and incubated with the membranes at 4 C overnight. The
WB
Showing 1-1 of 1 papers.
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