CHMP4C Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | WB |
|---|---|
| Recommended Dilution | WB 1:500, IHC 1:150 |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide conjugated to KLH derived from C terminal of Human CHMP4C. |
| Buffer | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide |
| Concentration | 1 mg/ml |
| Purification | Purified from the immunized serum by affinity chromatography (Protein A/G) |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | 26.2 kDa |
| Gene Name | charged multivesicular body protein 4C |
| Database Link | |
| Background | CHMP4C belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 PubMed 16730941). [supplied by OMIM, Mar |
| Synonyms | Shax3; SNF7-3; VPS32C |
| Reference Data | |
| Protein Categories | Cytokines, Intracellular Proteins |
| Protein Pathways | Endocytosis |
Reviews
Documents
| Product Manuals |
| FAQs |
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Resources
Other antibodies (1)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| TA890004S | Rabbit polyclonal CHMP4C Antibody | 30 ul |
$188.00
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Citations
Upregulation of the ESCRT pathway and multivesicular bodies accelerates degradation of proteins associated with neurodegeneration
Benyair, Giridharan, Rivero-Ríos et al
Autophagy Reports (2023) 2 (1) DOI: 10.1080/27694127.2023.2166722
Benyair, Giridharan, Rivero-Ríos et al
Autophagy Reports (2023) 2 (1) DOI: 10.1080/27694127.2023.2166722
Cited by 14
AI Summary: OriGene contributed the CHMP4C antibody (TA890004S) to this study, which was used to investigate the role of ESCRT pathway components in protein degradation related to neurodegeneration.
Snippet: (Cell signaling, 2232);Vps4A (Santa Cruz, sc-393428);CHMP4A (Kindly provided by Phyllis Hanson, University of Michigan);CHMP4B (Kindly provided by Phyllis Hanson, University of Michigan);CHMP4C (Origene, TA890004S);Donkey anti mouse hrp (Jackson immuno-research, 715-035-150);Goat anti rabbit hrp (Jackson immuno-research, 111-035-144);Goat anti mouse 488 (Thermo, A32723);Goat anti rabbit 5
A non-envelopment role for the ESCRT-III complex during HCMV infection
Streck, Carmichael, Buchkovich
J. Virol. (2018)
Streck, Carmichael, Buchkovich
J. Virol. (2018)
AI Summary: OriGene’s CHMP4C antibody was used in this study to investigate the role of ESCRT-III subunits during HCMV infection, specifically helping to assess the involvement of CHMP4C in viral envelopment and spread.
Snippet: following antibodies: CMV pp28 (5C3, Virusys), CMV pp52 (CH13, Santa Cruz), CMV 210 pp150 (gift from David Spector), CMV gB (Virusys), Actin (EMD Millipore), EphA2 (Cell 211 Signaling), CHMP6 (Proteintech), CHMP4B (Proteintech), CHMP4C (Origene), 212
Showing 1-2 of 2 papers.
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