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TrkA (NTRK1) Mouse Monoclonal Antibody [Clone ID: OTI5B6]

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SKU
TA806413
NTRK1 mouse monoclonal antibody, clone OTI5B6 (formerly 5B6)
Size:
100 ul 30 ul
Formulation:
Standard Carrier-free
Conjugation:
Unconjugated Biotin HRP
  $447.00
In Stock*
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View other "TrkA or NM_002529" antibodies

Specifications
Specifications
Product Data
Clone Name OTI5B6
Application IHC, WB
Recommended Dilution WB 1:2000, IHC 1:150
Reactivity Human, Mouse, Rat
Antibody Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Human recombinant protein fragment corresponding to amino acids 440-796 of human NTRK1(NP_002520) produced in E.coli.
Buffer PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide
Concentration 1 mg/ml
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Blue Ice
Predicted Protein Size 87.3 kDa
Gene Name neurotrophic receptor tyrosine kinase 1
Database Link
Background This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. provided by RefSeq, Jul 2008
Synonyms MTC; p140-TrkA; TRK; Trk-A; TRK1; TRKA
Reference Data
Protein Categories Cancer: Brain and CNS, Cancer: Endocrine, Enzyme: Kinases, Growth Factors, Intracellular Proteins, Membrane Proteins, Nervous system Diseases
Protein Families Druggable Genome, Protein Kinase, Transmembrane
Protein Pathways Apoptosis, Endocytosis, MAPK signaling pathway, Neurotrophin signaling pathway, Pathways in cancer, Thyroid cancer
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Other "OTI5B6" antibodies (4)
SKU Description Size Price
CF806413 Carrier-free (BSA/glycerol-free) NTRK1 mouse monoclonal antibody, clone OTI5B6 (formerly 5B6) 100 ug
$620.00
TA806413AM NTRK1 mouse monoclonal antibody, clone OTI5B6 (formerly 5B6), Biotinylated 100 ul
$509.00
TA806413BM NTRK1 mouse monoclonal antibody, clone OTI5B6 (formerly 5B6), HRP conjugated 100 ul
$509.00
TA806413S NTRK1 mouse monoclonal antibody, clone OTI5B6 (formerly 5B6) 30 ul
$200.00

file-alt Citations

Pathological and Prognostic Characterization of Craniopharyngioma Based on the Expression of TrkA, β-Catenin, Cell Cycle Markers, and BRAF V600E Mutation
Xu, Ge, Cheng et al
Front Endocrinol (Lausanne) (2022) 13, 859381 DOI: 10.3389/fendo.2022.859381
Cited by 6
AI Summary: OriGene products contributed to this study by providing the NTRK1 (TrkA) antibody (catalog #TA505011) and the BRAF (V600E Mutant Specific) antibody (catalog #TA802643), which were used for immunohistochemical analysis of TrkA and BRAF V600E expression in craniopharyngioma specimens.
FigureFigureFigure
Cytoplasmic TrkA Expression as a Screen for Detecting NTRK1 Fusions in Colorectal Cancer
Choi, Won, Lee et al
Transl Oncol (2018) 11 (3), 764-770 DOI: 10.1016/j.tranon.2018.03.011
AI Summary: OriGene’s anti-TrkA C-terminal monoclonal antibody (TA806413) was used to detect TrkA protein expression in tissue samples, enabling the study’s assessment of immunohistochemistry as a screening method for NTRK1 gene fusions in colorectal cancer.
Snippet: approved protocols. Briefly, TrkA expression was confirmed in deparaffinized, protease-treated FFPE tissue sections using an anti-TrkA C-terminal monoclonal antibody (TA806413;OriGene, Rockville, MD, US). Brain ganglions
Showing 1-2 of 2 papers.
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