Topoisomerase II alpha (TOP2A) Mouse Monoclonal Antibody [Clone ID: OTI2A9]
$447.00
In Stock*
Specifications
| Product Data | |
| Clone Name | OTI2A9 |
|---|---|
| Application | IHC, WB |
| Recommended Dilution | WB 1:2000, IHC 1:150 |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Mouse |
| Isotype | IgG2b |
| Clonality | Monoclonal |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1100-1531 of human TOP2A(NP_001058) produced in E.coli. |
| Buffer | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide. |
| Concentration | 1 mg/ml |
| Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | 174.2 kDa |
| Gene Name | topoisomerase (DNA) II alpha |
| Database Link | |
| Background | This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq, Jul |
| Synonyms | TOP2; TOP2alpha; TOPIIA; TP2A |
| Reference Data | |
| Protein Categories | Intracellular Proteins |
| Protein Families | Druggable Genome |
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Resources
Other "OTI2A9" antibodies (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| CF802384 | Carrier-free (BSA/glycerol-free) TOP2A mouse monoclonal antibody, clone OTI2A9 (formerly 2A9) | 100 ug |
$620.00
|
|
| TA802384AM | TOP2A mouse monoclonal antibody,clone 2A9, Biotinylated | 100 ul |
$509.00
|
|
| TA802384BM | TOP2A mouse monoclonal antibody,clone 2A9, HRP conjugated | 100 ul |
$509.00
|
|
| TA802384S | TOP2A mouse monoclonal antibody, clone OTI2A9 (formerly 2A9) | 30 ul |
$200.00
|
|
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