Topoisomerase II alpha (TOP2A) Mouse Monoclonal Antibody [Clone ID: OTI2A9]
SKU
CF802384
Carrier-free (BSA/glycerol-free) TOP2A mouse monoclonal antibody, clone OTI2A9 (formerly 2A9)
$620.00
3 Days*
Specifications
| Product Data | |
| Clone Name | OTI2A9 |
|---|---|
| Application | IHC, WB |
| Recommended Dilution | WB 1:2000, IHC 1:150 |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Mouse |
| Isotype | IgG2b |
| Clonality | Monoclonal |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1100-1531 of human TOP2A(NP_001058) produced in E.coli. |
| Buffer | Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose) |
| Reconstitution Method | For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific) |
| Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Ambient |
| Predicted Protein Size | 174.2 kDa |
| Gene Name | DNA topoisomerase II alpha |
| Database Link | |
| Background | This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq, Jul |
| Synonyms | TOP2; TOP2alpha; TOPIIA; TP2A |
| Reference Data | |
| Protein Categories | Intracellular Proteins |
| Protein Families | Druggable Genome |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other "OTI2A9" antibodies (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| TA802384 | TOP2A mouse monoclonal antibody, clone OTI2A9 (formerly 2A9) | 100 ul |
$447.00
|
|
| TA802384AM | TOP2A mouse monoclonal antibody,clone 2A9, Biotinylated | 100 ul |
$509.00
|
|
| TA802384BM | TOP2A mouse monoclonal antibody,clone 2A9, HRP conjugated | 100 ul |
$509.00
|
|
| TA802384S | TOP2A mouse monoclonal antibody, clone OTI2A9 (formerly 2A9) | 30 ul |
$200.00
|
|
Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
Related Products
- Price:
- Actual Price:
Welcome to OriGene AI!
I'm your AI-powered guide to everything OriGene.
Ask me anything:
- Product specs
- Ordering help
- Technical questions
- How to find exactly what your experiment needs
Prefer a live agent? Connect with us by clicking the green chat icon, as seen in the image below or email our team at custsupport@origene.com.
