HIF 2 alpha (EPAS1) Mouse Monoclonal Antibody [Clone ID: OTI2A6]
$447.00
In Stock*
Specifications
| Product Data | |
| Clone Name | OTI2A6 |
|---|---|
| Application | IHC, WB |
| Recommended Dilution | WB 1:2000, IHC 1:150 |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 584-870 of human EPAS1 (NP_001421) produced in E.coli. |
| Buffer | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide |
| Concentration | 1 mg/ml |
| Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | 96.3 kDa |
| Gene Name | endothelial PAS domain protein 1 |
| Database Link | |
| Background | This gene encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. The encoded protein contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels. Mutations in this gene are associated with erythrocytosis familial type 4. provided by RefSeq, Nov 2009 |
| Synonyms | bHLHe73; ECYT4; HIF2A; HLF; MOP2; PASD2 |
| Reference Data | |
| Protein Categories | Cancer: Endocrine, Cardiovascular diseases, Cytokines, Intracellular Proteins, Transciption Factors |
| Protein Families | Druggable Genome, Transcription Factors |
| Protein Pathways | Pathways in cancer, Renal cell carcinoma |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other "OTI2A6" antibodies (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| CF801749 | Carrier-free (BSA/glycerol-free) EPAS1 mouse monoclonal antibody, clone OTI2A6 (formerly 2A6) | 100 ug |
$620.00
|
|
| TA801749AM | EPAS1 mouse monoclonal antibody, clone OTI2A6 (formerly 2A6), Biotinylated | 100 ul |
$509.00
|
|
| TA801749BM | EPAS1 mouse monoclonal antibody, clone OTI2A6 (formerly 2A6), HRP conjugated | 100 ul |
$509.00
|
|
| TA801749S | EPAS1 mouse monoclonal antibody, clone OTI2A6 (formerly 2A6) | 30 ul |
$200.00
|
|
Citations
A Somatic HIF2α Mutation-Induced Multiple and Recurrent Pheochromocytoma/Paraganglioma with Polycythemia: Clinical Study with Literature Review
Liu, Wang, Tong et al
Endocr. Pathol. (2017)
Liu, Wang, Tong et al
Endocr. Pathol. (2017)
AI Summary: In this study, OriGene products—including VEGF antibody and First-Strand cDNA Synthesis kit—were used for immunohistochemistry and reverse transcription to analyze gene expression and protein levels related to the HIF2α mutation in pheochromocytoma/paraganglioma with polycythemia.
Snippet: Endocr Pathol Page 3. monoclonal antibodies against HIF-1α (Abcam, USA), HIF- 2α, VEGF (OriGene, MD, USA), and EPO (Santa Cruz, USA) were used. ... Reverse transcription was performed using the First- Strand cDNA Synthesis (OriGene, Rockville, MD, USA). ... Cite SaveSaving
Showing 1-1 of 1 papers.
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