CDK2 Mouse Monoclonal Antibody [Clone ID: OTI2A5]
$447.00
In Stock*
Specifications
| Product Data | |
| Clone Name | OTI2A5 |
|---|---|
| Application | FC, IF, Simple Western, WB |
| Recommended Dilution | WB 1:2000, IHC 1:150, IF 1:100, FLOW 1:100 ; Simple Western 1:20-1:50 |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Mouse |
| Isotype | IgG2a |
| Clonality | Monoclonal |
| Immunogen | Full length human recombinant protein of human CDK2 (NP_001789) produced in HEK293T cell. |
| Buffer | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide |
| Concentration | 0.8 mg/ml |
| Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | 33.7 kDa |
| Gene Name | cyclin dependent kinase 2 |
| Database Link | |
| Background | The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. This protein associates with and regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of this gene have been reported. provided by RefSeq |
| Synonyms | CDKN2; p33(CDK2) |
| Reference Data | |
| Protein Categories | Enzyme: Kinases, Intracellular Proteins |
| Protein Families | Druggable Genome, Protein Kinase |
| Protein Pathways | Cell cycle, Oocyte meiosis, p53 signaling pathway, Pathways in cancer, Progesterone-mediated oocyte maturation, Prostate cancer, Small cell lung cancer |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other "OTI2A5" antibodies (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| CF502915 | Carrier-free (BSA/glycerol-free) CDK2 mouse monoclonal antibody, clone OTI2A5 (formerly 2A5) | 100 ug |
$620.00
|
|
| TA502915AM | CDK2 mouse monoclonal antibody, clone OTI2A5 (formerly 2A5), Biotinylated | 100 ul |
$509.00
|
|
| TA502915BM | CDK2 mouse monoclonal antibody, clone OTI2A5 (formerly 2A5), HRP conjugated | 100 ul |
$509.00
|
|
| TA502915S | CDK2 mouse monoclonal antibody, clone OTI2A5 (formerly 2A5) | 30 ul |
$200.00
|
|
Citations
Clinical CDK4/6 inhibitors induce selective and immediate dissociation of p21 from cyclin D-CDK4 to inhibit CDK2
Pack, Daigh, Chung et al
Nat Commun (2021) 12 (1), 3356 DOI: 10.1038/s41467-021-23612-z
Pack, Daigh, Chung et al
Nat Commun (2021) 12 (1), 3356 DOI: 10.1038/s41467-021-23612-z
Cited by 107
AI Summary: OriGene’s anti-CDK2 antibody (OTI2A5) was used for western blot analysis to detect CDK2 in immunoprecipitation experiments, helping elucidate how CDK4/6 inhibitors affect CDK complex stability in cancer cells.
Snippet: above. For MCF7 and T-47D experiments, cycling cells were used for the IP protocol outlined above. IPs were evaluated by western blot using α-p21, α-FLAG (Sigma F3165, 1:1000), and α-CDK2 (Origene OTI2A5, 1:2000). For
Showing 1-1 of 1 papers.
Powered by BizGenius
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
Related Products
- Price:
- Actual Price:
Welcome to OriGene AI!
I'm your AI-powered guide to everything OriGene.
Ask me anything:
- Product specs
- Ordering help
- Technical questions
- How to find exactly what your experiment needs
Prefer a live agent? Connect with us by clicking the green chat icon, as seen in the image below or email our team at custsupport@origene.com.
