RIC8 (RIC8A) Mouse Monoclonal Antibody [Clone ID: OTI3G3]
$200.00
2 Days*
Specifications
| Product Data | |
| Clone Name | OTI3G3 |
|---|---|
| Application | IF, IHC, WB |
| Recommended Dilution | WB 1:1000, IHC 1:50, IF 1:100 |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | Full length human recombinant protein of human RIC8A (NP_068751) produced in HEK293T cell. |
| Buffer | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide |
| Concentration | 0.83 mg/ml |
| Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | 59.6 kDa |
| Gene Name | RIC8 guanine nucleotide exchange factor A |
| Database Link | |
| Background | Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation |
| Synonyms | RIC8 |
| Reference Data | |
| Protein Categories | Intracellular Proteins |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other "OTI3G3" antibodies (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| CF501055 | Carrier-free (BSA/glycerol-free) RIC8A mouse monoclonal antibody, clone OTI3G3 (formerly 3G3) | 100 ug |
$620.00
|
|
| TA501055 | Anti-RIC8A (RIC8) mouse monoclonal antibody, clone OTI3G3 (formerly 3G3) | 100 ul |
$447.00
|
|
| TA501055AM | Anti-RIC8A (RIC8) mouse monoclonal antibody, clone OTI3G3 (formerly 3G3), Biotinylated | 100 ul |
$509.00
|
|
| TA501055BM | Anti-RIC8A (RIC8) mouse monoclonal antibody, clone OTI3G3 (formerly 3G3), HRP conjugated | 100 ul |
$509.00
|
|
Citations
Gα13 Stimulates the Tyrosine Phosphorylation of Ric-8A
Yan, Ha, Dhanasekaran
J Mol Signal (2015) 10, 3 DOI: 10.5334/1750-2187-10-3
Yan, Ha, Dhanasekaran
J Mol Signal (2015) 10, 3 DOI: 10.5334/1750-2187-10-3
Cited by 6
Gα13 Stimulates the Tyrosine Phosphorylation of Ric-8A
Yan, Ha
Journal of Molecular Signaling (2015)
Yan, Ha
Journal of Molecular Signaling (2015)
Snippet: For the endogenous protein immunoprecipitation, 1 mg of the total protein lysate was incubated with 1 µg of normal mouse-IgG, Gα 13 (clone 73.1;Santa Cruz Biotechnology, Santa Cruz, CA) or Ric-8A-antibody (clone 3G3, OriGene, Rockville, MD) for 2 hours. ... Cite SaveSaving
Showing 1-2 of 2 papers.
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