TrkB (NTRK2) Mouse Monoclonal Antibody [Clone ID: OTI2E1]
$447.00
In Stock*
Specifications
| Product Data | |
| Clone Name | OTI2E1 |
|---|---|
| Application | IF, IHC, WB |
| Recommended Dilution | WB 1:1000, IHC 1:150, IF 1:100 |
| Reactivity | Human |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | Full length human recombinant protein of human NTRK2 (NP_001007098) produced in HEK293T cell |
| Buffer | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide |
| Concentration | 1.17 mg/ml |
| Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | 92 kDa |
| Gene Name | neurotrophic receptor tyrosine kinase 2 |
| Database Link | |
| Background | This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternate transcriptional splice variants encoding different isoforms have been found for this gene |
| Synonyms | GP145-TrkB; trk-B; TRKB |
| Note | WB application: Only overexpression results are guaranteed, not endogenous. |
| Reference Data | |
| Protein Categories | Cancer: Brain and CNS, Enzyme: Kinases, Growth Factors, Intracellular Proteins, Membrane Proteins, Nervous system Diseases |
| Protein Families | Druggable Genome, Protein Kinase, Transmembrane |
| Protein Pathways | MAPK signaling pathway, Neurotrophin signaling pathway |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other "OTI2E1" antibodies (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| CF500386 | Carrier-free (BSA/glycerol-free) NTRK2 mouse monoclonal antibody, clone OTI2E1 (formerly 2E1) | 100 ug |
$620.00
|
|
| TA500386AM | Anti-NTRK2 (TrkB ) mouse monoclonal antibody, clone OTI2E1 (formerly 2E1), Biotinylated | 100 ul |
$509.00
|
|
| TA500386BM | Anti-NTRK2 (TrkB ) mouse monoclonal antibody, clone OTI2E1 (formerly 2E1), HRP conjugated | 100 ul |
$509.00
|
|
| TA500386S | Anti-NTRK2 (TrkB ) mouse monoclonal antibody, clone OTI2E1 (formerly 2E1) | 30 ul |
$200.00
|
|
Citations
Rab8A promotes breast cancer progression by increasing surface expression of Tropomyosin-related kinase B
Liu, Zhang, Gao et al
Cancer Lett (2022) 535, 215629 DOI: 10.1016/j.canlet.2022.215629
Liu, Zhang, Gao et al
Cancer Lett (2022) 535, 215629 DOI: 10.1016/j.canlet.2022.215629
Cited by 10
AI Summary: OriGene's TrkB antibody (TA500386) was used in this study to detect and analyze TrkB protein expression, contributing to the investigation of Rab8A's role in breast cancer progression.
Snippet: Antibodies for Rab8A (55296-1-AP, Proteintech Group, Chicago, USA), TrkB (TA500386, OriGene, Wuxi, China) and BDNF (66292-1-ig, Proteintech Group, Chicago, USA) were used in this research. The tissues were photographed and analyzed under a microscope (OPTIKA B-150, ITALY). Barnes method was used for statistical analysis [13]
BDNF/TrkB signaling in pancreatic islet beta cells
Kalwat, Huang, McGlynn et al
bioRxiv (2018)
Kalwat, Huang, McGlynn et al
bioRxiv (2018)
Snippet: Page 1. BDNF/TrkB signaling in pancreatic islet beta cells 1 BDNF/TrkB signaling in pancreatic islet beta cells Michael A. Kalwat1*, Zhimin Huang1,2#, Kathleen McGlynn1, and Melanie H. Cobb1* Department of 1Phamacology View as HTML;TrkB Mouse 145, 95 Origene TA500386 - 1:100 TrkB Mouse 145, 95 Santa Cruz sc-377218 1:100 Anti-human
Human brain proteins showing neuron-specific interactions with γ-secretase
Inoue, Hur, Kihara et al
FEBS J. (2015)
Inoue, Hur, Kihara et al
FEBS J. (2015)
Cited by 19
AI Summary: In this study, the OriGene antibody TA500386 was used to detect Trk-B protein in neurons, contributing to the analysis of neuron-specific interactions between γ-secretase and associated proteins relevant to Alzheimer’s disease research.
Showing 1-3 of 3 papers.
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