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PDX1 Mouse Monoclonal Antibody [Clone ID: OTI2A12]

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SKU
TA500038
Pdx1 mouse monoclonal antibody, clone OTI2A12 (formerly 2A12)
Size:
100 ul 30 ul
Formulation:
Standard Carrier-free
Conjugation:
Unconjugated Biotin HRP
  $447.00
In Stock*
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View other "PDX1 or NM_000209" antibodies

Specifications
Specifications
Product Data
Clone Name OTI2A12
Application IF, IHC
Recommended Dilution IHC 1:50
IF 1:50~100
Reactivity Human, Mouse, Rat
Antibody Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Full length human recombinant protein of human PDX1 (NP_000200) produced in E.coli.
Buffer PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide
Concentration 1 mg/ml
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Blue Ice
Predicted Protein Size 30.6 kDa
Gene Name pancreatic and duodenal homeobox 1
Database Link
Background Pdx1 is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. It is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in PDX1 gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4).
Synonyms GSF; IDX-1; IPF1; IUF1; MODY4; PAGEN1; PDX-1; STF-1
Reference Data
Protein Categories Cytokines, Endocrine and metabolic diseases, Intracellular Proteins, Transciption Factors
Protein Families Embryonic stem cells, ES Cell Differentiation/IPS, Induced pluripotent stem cells, Transcription Factors
Protein Pathways Maturity onset diabetes of the young, Type II diabetes mellitus
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Other "OTI2A12" antibodies (4)
SKU Description Size Price
CF500038 Carrier-free (BSA/glycerol-free) Pdx1 mouse monoclonal antibody, clone OTI2A12 (formerly 2A12) 100 ug
$620.00
TA500038AM Pdx1 mouse monoclonal antibody, clone 2A12, Biotinylated 100 ul
$509.00
TA500038BM Pdx1 mouse monoclonal antibody, clone 2A12, HRP conjugated 100 ul
$509.00
TA500038S Pdx1 mouse monoclonal antibody, clone OTI2A12 (formerly 2A12) 30 ul
$200.00

file-alt Citations

Atypical KCNQ1/Kv7 channel function in a neonatal diabetes patient: Hypersecretion preceded the failure of pancreatic β-cells
Zhou, Gong, Pande et al
iScience (2024) 27 (7), 110291 DOI: 10.1016/j.isci.2024.110291
Cited by 7
AI Summary: In this study, the OriGene PDX1 Mouse Monoclonal Antibody (Cat#TA500038) was used to detect PDX1 protein, aiding the investigation of pancreatic β-cell function in a neonatal diabetes patient.
Snippet: Rabbit IgG Isotype Control (Alexa Fluor 488 Conjugate) Cell Signaling Technology Cat#4340S PDX1 Mouse Monoclonal Antibody Origene Cat#TA500038 Homeobox protein Nkx-6.1 Developmental Studies Cat#F55A12 Purified Mouse Anti-Ki-67 BD Biosciences Cat#550609
Interferon-γ Decreases Nuclear Localization of Pdx-1 and Triggers β-Cell Dysfunction in Chronic Pancreatitis
Pondugala, Sasikala, Guduru et al
J. Interferon Cytokine Res. (2015)
Cited by 23
AI Summary: OriGene’s Pdx-1 primary antibody was used to detect and analyze the nuclear localization of Pdx-1 in pancreatic tissues and islets, enabling the study to demonstrate how interferon-γ impairs β-cell function in chronic pancreatitis.
Snippet: retrieval for Pdx-1was conducted using 10 mM sodium citrate at 95°C for 30 s. The sections were washed twice with PBS at room temperature, blocked with 5% FBS for 1 h at room temperature and left overnight at 4°C with Pdx-1 primary antibody (OriGene Technologies ... Cite SaveSaving
WB IF IHC
Showing 1-2 of 2 papers.
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