CD11b (ITGAM) Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | WB |
|---|---|
| Recommended Dilution | WB: 1:500~1:1000 |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | Recombinant full length Human CD11B (630aa-1104aa). |
| Specificity | CD11B (I1) polyclonal antibody detects endogenous levels of CD11B protein. |
| Buffer | Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 |
| Concentration | 1mg/ml |
| Conjugation | Unconjugated |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. |
| Stability | 1 year |
| Shipping | Blue Ice |
| Predicted Protein Size | ~ 170 kDa |
| Gene Name | integrin subunit alpha M |
| Database Link | |
| Background | Integrin αM, also designated complement component receptor-3 α, CD11b (p170), macrophage antigen a polypeptide, cell surface glycoprotein Mac-1 a subunit, MAC1A, MO1A and ITGAM) is a cell adhesion molecule that acts as a receptor for cell surface ligands such as intracellular adhesion molecules (ICAMs) or soluble ligands. Integrins are heterodimeric proteins that contain an a chain and b chain. Integrin αM combines with the Integrin β2 to form a leukocyte-specific integrin referred to as macrophage receptor 1 (Mac-1), or inactivated-C3b (iC3b) receptor 3 (CR3). Integrin αM/β2 is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. |
| Synonyms | CD11 antigen-like family member B; CD11B; CD11b; Cell surface glycoprotein MAC-1 subunit alpha; CR-3 alpha chain; CR-3α; CR3A; CR3α; Integrin alpha-M; Integrin αM; ITGAM; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor |
| Note | For research use only, not for use in diagnostic procedure. |
| Reference Data | |
| Protein Categories | CD Markers, Intracellular Proteins, Membrane Proteins |
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