SLC16A5 Rabbit Polyclonal Antibody

SKU TA392677

SLC16A5 (A193) polyclonal antibody

Product Data

• Application: WB
• Recommended Dilution: WB: 1:500~1:1000
• Reactivity: Human, Mouse, Rat
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide, corresponding to amino acids 161-210 of Human SLC16A5.
• Specificity: SLC16A5 (A193) polyclonal antibody detects endogenous levels of SLC16A5 protein.
• Buffer: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Concentration: 1mg/ml
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
• Stability: 1 year
• Shipping: Blue Ice
• Predicted Protein Size: ~ 55 kDa
• Gene Name: solute carrier family 16 member 5
• Database Link:
  O15375
• Background: Monocarboxylates, such as lactate and pyruvate, play an integral role in cellular metabolism. Lactic acid is produced in large quantities as a result of glycolysis, which provides the majority of ATP to cells under normal physiological conditions. However, accumulation of lactic acid leads to a decrease in intracellular pH and cessation of glycolysis. In order for glycolysis to continue at a high rate, lactic acid must be transported out of the cell. This transport process is carried out by a family of monocarboxylate transporters (MCTs), which function as proton symports and are stereoselective for L-lactate. The MCT family consists of at least eight members, MCT1-8, which contain between 10-12 transmembrane-helical (TM) domains, with the amino and carboxy termini located in the cytoplasm. MCT6 is highly expressed in the kidneys and is thought to have a specificity for bumetanide, a loop diuretic involved in the treatment of edema. The high substrate specificity of MCT6 suggests a possible role in therapeutic drug transport and trafficking across the plasma membrane.
• Synonyms: MCT 5; MCT5; MCT 6; MCT6; Monocarboxylate transporter 5; Monocarboxylate transporter 6; SLC16A5; Solute carrier family 16 member 5
• Note: For research use only, not for use in diagnostic procedure.

Reference Data