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Chrnb2 Rabbit Polyclonal Antibody

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SKU
TA389023
Anti-Nicotinic Acetylcholine Receptor (nAChR) β2 Antibody
Size:
100 ul
Conjugation:
Unconjugated
  $610.00
5 Days*
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Specifications
Specifications
Product Data
Application WB
Recommended Dilution WB: 1:1000
WB Brain: 1:1000
Reactivity Mouse, Rat
Antibody Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Fusion protein from the cytoplasmic loop of the β2 subunit of mouse nAChR.
Specificity Specific for endogenous levels of the ~52 kDa nAChRβ2 protein.
Buffer 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.
Concentration lot specific
Purification Antigen Affinity Purified from Pooled Serum
Conjugation Unconjugated
Storage Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
Stability After date of receipt, stable for at least 1 year at -20°C.
Shipping Blue Ice
Predicted Protein Size 52
Gene Name cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)
Database Link
Background Nicotinic acetylcholine receptors (nAChRs) are ionotropic, cholinergic receptors that are divided into 2 types; muscle type and neuronal type. Neuronal nAChRs are pentameric ion channels consisting of 5 identical (homopentamers) or different (heteropentamers) subunits. Heteropentameric neuronal nAChRs mediate fast synaptic transmission in the autonomic nervous system. The predominant hetero-oligomeric nAChR in the CNS contain the subunits α4β2, whereas α3β4 prevail in the PNS. However, the expression of these subunits varies not only by region but also during development (Scholze et al 2011). In the brain, β2-containing receptors greatly outnumber receptors that contain β4 (McGehee & Role, 1995; Albuquerque, et al., 2009), and in most brain regions, targeted deletion of the β2 subunit virtually abolishes 3H-epibatidine binding and receptor autoradiography (Zoli, et al., 1998) due to the absence of a β subunit required to form functional nAChRs (Champtiaux & Changeux, 2004).
Synonyms EFNL3; nAChRB2
Note Prepared from pooled rabbit serum by affinity purification using a column to which the fusion protein antigen was coupled.
Reference Data
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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