CD8A Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | ELISA, IHC, WB |
|---|---|
| Recommended Dilution | WB,1:100 - 1:500 IHC-P,1:50 - 1:200 ELISA,Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements. |
| Reactivity | Human, Mouse |
| Modification | Unmodified |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Buffer | Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |
| Concentration | lot specific |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage | Store at -20℃. Avoid freeze / thaw cycles. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Predicted Protein Size | 26kDa |
| Gene Name | CD8a molecule |
| Database Link | |
| Background | The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene. The major protein isoforms of this gene differ by the presence or absence of a transmembrane domain and thus differ in being a membrane-anchored or secreted protein. |
| Synonyms | CD8; Leu2; MAL; OTTHUMP00000203721; p32 |
| Reference Data | |
| Protein Categories | ADC Targets, CD Markers, Immune system diseases, Intracellular Proteins, Membrane Proteins |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Citations
TMEM160 promotes tumor immune evasion and radiotherapy resistance via PD-L1 binding in colorectal cancer
Dai, Wu, Ruan et al
Cell Commun Signal (2024) 22 (1), 168 DOI: 10.1186/s12964-024-01541-w
Dai, Wu, Ruan et al
Cell Commun Signal (2024) 22 (1), 168 DOI: 10.1186/s12964-024-01541-w
Cited by 22
AI Summary: OriGene’s CD8A antibody (TA374492) was used in this study to evaluate CD8A expression in colorectal cancer tissues, contributing to the analysis of immune cell infiltration and the relationship between TMEM160, PD-L1, and immune evasion.
Snippet: Group Corp, Rosemont, USA), Myc (16286–1-AP, Proteintech Group Corp, Rosemont, USA), His (66005–1-Ig, Proteintech Group Corp, Rosemont, USA), CD8A (TA374492, ORIGENE Corp, Wuxi, China), and GAPDH (60004–1-Ig, Proteintech Group Corp, Rosemont, USA). The antibodies were used according to the manufacturers’ protocols
Showing 1-1 of 1 papers.
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