CLASP2 Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | IHC |
|---|---|
| Recommended Dilution | IHC: 25-100 Positive control: Human liver cancer Predicted cell location: Cytoplasm |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | Fusion protein of human CLASP2 |
| Buffer | pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Concentration | lot specific |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage | Store at -20°C. |
| Stability | 1 year |
| Shipping | Blue Ice |
| Gene Name | cytoplasmic linker associated protein 2 |
| Database Link | |
| Background | CLASP2 (cytoplasmic linker associated protein 2), also known as KIAA0627 or hOrbit2, is a 1,294 amino acid protein that contains five HEAT repeats and localizes to the cytoplasm and the cytoskeleton, as well as to the kinetochore and the golgi apparatus. Expressed primarily in brain tissue, CLASP2 functions as a microtubule plus-end tracking protein that regulates the stability of dynamic microtubules and is required for the proper polarization of cytoplasmic microtubule arrays in migrating cells. CLASP2 interacts with EB1, EB3, ELKS and CLIP-115 and, in addition to stabilizing microtubules, plays an important role in maintaining the stability of the kinetochore and is crucial for proper chromosomal alignment. CLASP2 is subject to phosphorylation by GSK-3β, an event that is thought to negatively regulate the ability of CLASP2 to bind to microtubules. Two isoforms of CLASP2, designated beta and gamma, exist due to alternative splicing events. |
| Synonyms | hOrbit2; KIAA0627 |
| Reference Data | |
| Protein Categories | Growth Factors, Intracellular Proteins |
Reviews
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Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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