RASGRP1 Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | WB |
|---|---|
| Reactivity | Human |
| Antibody Host | Rabbit |
| Clonality | Polyclonal |
| Specificity | Expected reactivity: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat Homology: Cow: 86%; Dog: 93%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 79%; Rabbit: 79%; Rat: 93% |
| Buffer | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Concentration | lot specific |
| Purification | Affinity Purified |
| Conjugation | Unconjugated |
| Storage | For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Predicted Protein Size | 90kDa |
| Gene Name | RAS guanyl releasing protein 1 |
| Database Link | |
| Background | This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). |
| Synonyms | CALDAG-GEFI; CalDAG-GEFII; hRasGRP1; MGC129998; MGC129999; RASGRP; V |
| Reference Data | |
| Protein Categories | Immune system diseases, Intracellular Proteins |
| Protein Pathways | MAPK signaling pathway, T cell receptor signaling pathway |
Reviews
Documents
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Citations
Transcriptional-translational conflict is a barrier to cellular transformation and cancer progression
Jana, Brahma, Arora et al
Cancer Cell (2023) 41 (5), 853-870.e13 DOI: 10.1016/j.ccell.2023.03.021
Jana, Brahma, Arora et al
Cancer Cell (2023) 41 (5), 853-870.e13 DOI: 10.1016/j.ccell.2023.03.021
Cited by 61
AI Summary: In this study, OriGene's RASGRP1 rabbit polyclonal antibody (Cat# TA358534) was used to investigate the molecular mechanisms underlying transcriptional-translational conflict and its role in tumor suppression and cancer progression.
Snippet: We uncover a tumor-suppressive process in urothelium called transcriptional-translational conflict caused by deregulation of the central chromatin remodeling component Save;p70RSK, rabbit Cell Signaling Technology Cat# 9202;RRID: AB_331676 RASGRP1, rabbit polyclonal Origene Cat# TA358534 p44/42 MAPK (Erk1/2), rabbit Cell Signaling Technology Cat# 9102;RRID: AB_330744
Showing 1-1 of 1 papers.
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