Prom1 Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | WB |
|---|---|
| Reactivity | Mouse |
| Antibody Host | Rabbit |
| Clonality | Polyclonal |
| Specificity | Expected reactivity: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rat, Zebrafish Homology: Cow: 86%; Dog: 86%; Guinea Pig: 93%; Horse: 92%; Human: 100%; Mouse: 85%; Rat: 91%; Zebrafish: 92% |
| Buffer | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. Note that this product is shipped as lyophilized powder to China customers. |
| Concentration | lot specific |
| Purification | Affinity Purified |
| Conjugation | Unconjugated |
| Storage | For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Predicted Protein Size | 95kDa |
| Gene Name | prominin 1 |
| Database Link | |
| Background | Prom1 binds cholesterol in cholesterol-containing plasma membrane microdomains. It is rroposed to play a role in apical plasma membrane organization of epithelial cells. During early during retinal development, Prom1 acts as a key regulator of disk morphogenesis. Prom1 is involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner. |
| Synonyms | AC133; CD133; CORD12; hProminin; MCDR2; MSTP061; PROML1; RP41; STGD4 |
| Reference Data | |
| Protein Categories | CD Markers, Intracellular Proteins, Membrane Proteins, Nervous system Diseases |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Citations
Prominin-1 Is a Novel Regulator of Autophagy in the Human Retinal Pigment Epithelium
Bhattacharya, Yin, Winborn et al
Invest. Ophthalmol. Vis. Sci. (2017) 58 (4), 2366-2387 DOI: 10.1167/iovs.16-21162
Bhattacharya, Yin, Winborn et al
Invest. Ophthalmol. Vis. Sci. (2017) 58 (4), 2366-2387 DOI: 10.1167/iovs.16-21162
AI Summary: OriGene’s rabbit polyclonal Prom1 antibody was used in this study to detect Prominin-1 expression, thereby enabling the investigation of its role as a regulator of autophagy in human retinal pigment epithelium cells.
Snippet: rabbit polyclonal Prom1 antibody (OriGene, Rockville, MD, USA, and Aviva Systems Biology Corp., San Diego, CA, USA);anti-mouse Prom1/CD133 antibodies (Miltenyi Biotec, Auburn, CA, USA, and GeneTex, Inc., Irvine, CA, USA)
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