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IRAK4 Mouse Monoclonal Antibody [Clone ID: A8A8]

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SKU
TA354510
Mouse anti IRAK4(pT345) Monoclonal Antibody
Size:
100 ug
Conjugation:
Unconjugated
  $430.00
5 Days*
Bulk/Customize

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View other "IRAK4 or NM_001114182" antibodies

Specifications
Specifications
Product Data
Clone Name A8A8
Application Dot, WB
Recommended Dilution WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml
Reactivity Bovine, Dog, Human, Mouse
Antibody Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen A synthetic peptide surrounding to the epitope -VMTSR- with a phosphorylation site at Thr345 of human IRAK-4 protein. This sequence is identical among human, mouse, bovine and dog.
Buffer This affinity purified antibody is supplied in sterile Tris-buffered saline (pH7.2) containing antibody stabilizer.
Purification The mouse IgG is purified by Protein A-Affinity Chromatography according to Isotyping
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Blue Ice
Predicted Protein Size ~51 kDa
Gene Name interleukin 1 receptor associated kinase 4
Database Link
Background IRAK (IL-1 associated serine/threonine kinase) is a critical regulator of Interleukin-1 (IL-1) induced activation of the NFkappaB pathway. IL-1 stimulation leads to the recruitment of interleukin-1 receptor-associated kinase (IRAK) to the IL-1 receptor, where IRAK is phosphorylated, ubiquitinated, and eventually degraded. There are four members (IRAK1, IRAK2, IRAK3/IRAK-M and IRAK4). IRAK-4, recently found another IRAK family member necessary for the IL-1 pathway, is able to phosphorylate IRAK in vitro suggests that IRAK-4 might be the IRAK kinase. IRAK4 is required for the efficient recruitment of IRAK to the IL-1 receptor complex.
Synonyms IPD1; IRAK-4; NY-REN-64; REN64
Reference Data
Protein Categories Cytokines, Enzyme: Kinases, Immune system diseases, Intracellular Proteins
Protein Families Druggable Genome, Protein Kinase
Protein Pathways Apoptosis, Neurotrophin signaling pathway, Toll-like receptor signaling pathway
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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