CISH Rabbit Polyclonal Antibody

CAT#: TA354443

Rabbit anti CIS-1 Polyclonal Antibody

Product Images

WB: The tissue lysate derived from mouse kidney was immunoprobed by Rabbit anti-CIS-1 antibody at 1:500. An immunoreactive band is observed around ~.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A synthetic peptide corresponding to internal sequence of CIS-1 protein from human, rat and mouse origins.
• Formulation: This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
• Purification: The Rabbit IgG is purified by Epitope Affinity Purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 29 kDa
• Gene Name: cytokine inducible SH2 containing protein
• Database Link:
  NP_037456
  Entrez Gene 1154 Human
  UniProt ID Q9NSE2
• Background: Cytokines induce a variety of biological responses by binding to specific cell surface receptors and activating cytoplasmic signal transduction pathways which are suppressed by other transcriptional factors. Proteins that mediate these signals from the cell surface to the nucleus include JAKs and STATs, while SOCS (Suppressor of cytokine signaling) proteins inhibit those signaling. The SOCS family comprises at least 8 members, SOCS1 to SOCS7 and CIS (cytokine inducible SH2 containing protein). Structurally, the SOCS proteins are composed of an N terminal region of variable length and amino acid composition, a central SH2 domain, and a previously unrecognized C terminal motif named the SOCS box. SOCS 1 inhibition of signal transduction appears to occur by binding to and inhibiting the catalytic activity of members of JAK family of cytoplasmic kinases (direct JAK2 kinase inhibition). CIS1 is involved in EPO signaling.
• Synonyms: BACTS2; CIS; CIS-1; G18; SOCS

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Jak-STAT signaling pathway