WNT2 Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | IHC, WB |
|---|---|
| Recommended Dilution | WB: 500-2000 WB positive control: Human endometrial cancer tissue IHC: 30-150 Positive control: Human brain Predicted cell location: Cytoplasm |
| Reactivity | Human, Mouse |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human WNT2 |
| Buffer | pH7.4 PBS, 0.05% NaN3, 40% Glyceroln |
| Concentration | lot specific |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | 40 kDa |
| Gene Name | Wnt family member 2 |
| Database Link | |
| Background | This gene is a member of the WNT gene family. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Alternatively spliced transcript variants have been identified for this gene. |
| Synonyms | INT1L1; IRP |
| Reference Data | |
| Protein Categories | Cytokines, Growth Factors, Secreated Proteins |
| Protein Families | Adult stem cells, Cancer stem cells, ES Cell Differentiation/IPS, Secreted Protein, Stem cell relevant signaling - Wnt Signaling pathway |
| Protein Pathways | Basal cell carcinoma, Hedgehog signaling pathway, Melanogenesis, Pathways in cancer, Wnt signaling pathway |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Citations
Cancer‐associated fibroblasts secrete Wnt2 to promote cancer progression in colorectal cancer
Aizawa, Karasawa, Funayama et al
Cancer Med (2019) 8 (14), 6370-6382 DOI: 10.1002/cam4.2523
Aizawa, Karasawa, Funayama et al
Cancer Med (2019) 8 (14), 6370-6382 DOI: 10.1002/cam4.2523
AI Summary: OriGene’s rabbit anti-Wnt2 polyclonal antibody was used for immunohistochemical analysis to detect Wnt2 expression in cancer-associated fibroblasts and stroma within colorectal cancer tissues, helping to elucidate the role of Wnt2 in cancer progression.
Snippet: Then, samples were incubated with rabbit anti‐ Wnt2 polyclonal antibody (OriGene;dilution 1:300) as the primary antibodies, overnight at 4°C. After blocking the en- dogenous peroxidase activity by methanol containing 0.3% hydrogen peroxide (H2O2), the sections
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