EI24 Rabbit Polyclonal Antibody

CAT#: TA351836

Rabbit Polyclonal Anti-EI24 Antibody

Product Images

Immunohistochemistry of paraffin-embedded Human liver cancer tissue using TA351836 (EI24 Antibody) at dilution 1/25 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human liver cancer tissue using TA351836 (EI24 Antibody) at dilution 1/25, treated with synthetic peptide. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 10-50
  Positive control: Human liver cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide of human EI24
• Formulation: pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: EI24, autophagy associated transmembrane protein
• Database Link:
  NP_004870
  Entrez Gene 13663 MouseEntrez Gene 300514 RatEntrez Gene 9538 Human
  UniProt ID O14681
• Background: This gene encodes a putative tumor suppressor and has higher expression in p53-expressing cells than in control cells and is an immediate-early induction target of p53-mediated apoptosis. The encoded protein may suppress cell growth by inducing apoptotic cell death through the caspase 9 and mitochondrial pathways. This gene is located on human chromosome 11q24, a region frequently altered in cancers. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 1, 3, 7, and 8.
• Synonyms: EPG4; PIG8; TP53I8

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: p53 signaling pathway