SMOC2 Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | IHC, WB |
|---|---|
| Recommended Dilution | WB: 200-1000 WB positive control: Human placenta tissue IHC: 25-100 Positive control: Human cervical cancer Predicted cell location: Secreted |
| Reactivity | Human, Mouse |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human SMOC2 |
| Buffer | pH7.4 PBS, 0.05% NaN3, 40% Glyceroln |
| Concentration | lot specific |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | 50 kDa |
| Gene Name | SPARC related modular calcium binding 2 |
| Database Link | |
| Background | This gene encodes a member of the SPARC family (secreted protein acidic and rich in cysteine/osteonectin/BM-40), which are highly expressed during embryogenesis and wound healing. The gene product is a matricellular protein which promotes matrix assembly and can stimulate endothelial cell proliferation and migration, as well as angiogenic activity. Associated with pulmonary function, this secretory gene product contains a Kazal domain, two thymoglobulin type-1 domains, and two EF-hand calcium-binding domains. |
| Synonyms | bA37D8.1; bA270C4A.1; dJ421D16.1; DTDP1; MST117; MSTP117; MSTP140; SMAP2 |
| Reference Data | |
| Protein Categories | Growth Factors, Intracellular Proteins, Secreated Proteins |
| Protein Families | Secreted Protein |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Citations
EGFR controls transcriptional and metabolic rewiring in KRASG12D colorectal cancer
Krauß, Moreno-Viedma, Adachi-Fernandez et al
EMBO Mol Med (2025)
Krauß, Moreno-Viedma, Adachi-Fernandez et al
EMBO Mol Med (2025)
Cited by 12
AI Summary: In this study, the OriGene SMOC2 antibody (Cat# TA351730) was used to investigate the role of SMOC2 in mediating phenotypic and metabolic changes following EGFR deletion in KRAS-mutant colorectal cancer organoids.
Snippet: Anti-Ki67 (1:100) Abcam Cat# ab15580, RRID:AB_443209 Glucose Transporter GLUT1 antibody [EPR3915] (1:100,000) Abcam Cat# ab115730, RRID:AB_10903230 SMOC2 antibody (1:1000) Origene Cat# TA351730 HSP90 antibody (1:1000) Cell Signaling Technology Cat# 4874, RRID:AB_2121214 beta-Catenin (6B3) Rabbit mAb (1:1000) Cell Signaling Technology Cat# 9582, RRID:AB_823447
SMOC2, an intestinal stem cell marker, is an independent prognostic marker associated with better survival in colorectal cancers
Jang, Kim, Bae et al
Sci Rep (2020) 10 (1), 14591 DOI: 10.1038/s41598-020-71643-1
Jang, Kim, Bae et al
Sci Rep (2020) 10 (1), 14591 DOI: 10.1038/s41598-020-71643-1
Cited by 58
AI Summary: OriGene contributed to this study by providing the anti-SMOC2 antibody (catalog number: TA351730), which was used for immunohistochemical analysis to evaluate SMOC2 expression in colorectal cancer tissues.
Snippet: manufacturer's guidelines. The primary antibodies used were anti-SMOC2 (OriGene, Rockville, MD;1:30, catalog number: TA351730) and anti-β-catenin (Novocastra Laboratories, Newcastle, UK;17C2;1:800). The expression
Downregulation of SMOC2 expression in papillary thyroid carcinoma and its prognostic significance
Kim, Choi, Lee et al
Sci Rep (2020) 10 (1), 4853 DOI: 10.1038/s41598-020-61828-z
Kim, Choi, Lee et al
Sci Rep (2020) 10 (1), 4853 DOI: 10.1038/s41598-020-61828-z
Cited by 24
AI Summary: OriGene’s anti-SMOC2 antibody was used for immunohistochemical detection and evaluation of SMOC2 protein expression in papillary thyroid carcinoma tissue samples in this study.
Snippet: structions, immunohistochemistry was performed on 4-μm TMA sections using a Ventana BenchMark XT Staining systems (Leica Microsystems, Wetzlar, Germany). The primary antibodies used were anti-SMOC2 (OriGene, Rockville, MD;1:30) and anti-BRAF (V600E) (Spring Bioscience, VE1;1:50). Cytoplasmic SMOC2 staining was scored from 0 to 3 according to the stain intensity and each case was considered as p
Showing 1-3 of 3 papers.
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