SIGLEC8 Rabbit Polyclonal Antibody

CAT#: TA351666

Rabbit Polyclonal Anti-SIGLEC8 Antibody

Product Images

Gel: 8%SDS-PAGE Lysate: 40 μg Lane: Human liver tissue lysate Primary antibody: TA351666 (SIGLEC8 Antibody) at dilution 1/500 Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution Exposure time: 2 minutes

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  Immunohistochemistry of paraffin-embedded Human prostate cancer tissue using TA351666 (SIGLEC8 Antibody) at dilution 1/75 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human prostate cancer tissue using TA351666 (SIGLEC8 Antibody) at dilution 1/75, treated with synthetic peptide. (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human liver cancer tissue using TA351666 (SIGLEC8 Antibody) at dilution 1/75 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human liver cancer tissue using TA351666 (SIGLEC8 Antibody) at dilution 1/75, treated with synthetic peptide. (Original magnification: ×200)

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Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 500-2000
  WB positive control: Human liver tissue lysate
  IHC: 50-200
  Positive control: Human prostate cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide of human SIGLEC8
• Formulation: pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 54 kDa
• Gene Name: sialic acid binding Ig like lectin 8
• Database Link:
  NP_055257
  Entrez Gene 27181 Human
  UniProt ID Q9NYZ4
• Background: Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs, are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM, and a motif homologous to one identified in signaling lymphocyte activation molecule that mediates an association with SLAM-associated protein.
• Synonyms: SAF2; SIGLEC-8; SIGLEC8L

Reference Data

• Protein Families: Druggable Genome, Transmembrane