P3H3 Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | IHC, WB |
|---|---|
| Recommended Dilution | WB: 500-2000 WB positive control: A549 cells, mouse heart tissue and Hela cells IHC: 50-200 Positive control: Human rectal cancer Predicted cell location: Cytoplasm |
| Reactivity | Human, Mouse |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | Fusion protein of human LEPREL2 |
| Buffer | pH7.4 PBS, 0.05% NaN3, 40% Glyceroln |
| Concentration | lot specific |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | 82 kDa |
| Gene Name | prolyl 3-hydroxylase 3 |
| Database Link | |
| Background | The protein encoded by this gene belongs to the leprecan family of proteoglycans, which function as collagen prolyl hydroxylases that are required for proper collagen biosynthesis, folding and assembly. This protein, like other family members, is thought to reside in the endoplasmic reticulum. Epigenetic inactivation of this gene is associated with breast and other cancers, suggesting that it may function as a tumor suppressor. |
| Synonyms | GRCB; HSU47926; LEPREL2 |
| Reference Data | |
| Protein Categories | Intracellular Proteins |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Citations
Collagen prolyl hydroxylase 3 has a tumor suppressive activity in human lung cancer
Li, Chen, Ma et al
Exp. Cell Res. (2017)
Li, Chen, Ma et al
Exp. Cell Res. (2017)
AI Summary: OriGene contributed to this study by providing the full-length human-Leprel2 cDNA, which was used for functional analysis of P3H3's tumor suppressive role in lung cancer.
Snippet: A full-length human-Leprel2 cDNA purchased from Origene (Rockville, Maryland, United States) was cut by restriction enzymes EcoRI and NotI and cloned into a mammalian expression vector pcDNATM3.1/V5-His B (Thermo Fisher)
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