CD46 Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | IHC |
|---|---|
| Recommended Dilution | IHC: 25-100 Positive control: Human colon cancer Predicted cell location: Cytoplasm |
| Reactivity | Human |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | Fusion protein of human CD46 |
| Buffer | pH7.4 PBS, 0.05% NaN3, 40% Glyceroln |
| Concentration | lot specific |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Gene Name | CD46 molecule |
| Database Link | |
| Background | The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. |
| Synonyms | AHUS2; MCP; MIC10; TLX; TRA2.10 |
| Reference Data | |
| Protein Categories | ADC Targets, Cardiovascular diseases, CD Markers, Growth Factors, Intracellular Proteins, Membrane Proteins |
| Protein Families | Druggable Genome, Transmembrane |
| Protein Pathways | Complement and coagulation cascades |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Citations
Efficacy of CD46-targeting chimeric Ad5/35 adenoviral gene therapy for colorectal cancers
Cho, Do, Kwon et al
Oncotarget (2016) 7 (25), 38210-38223 DOI: 10.18632/oncotarget.9427
Cho, Do, Kwon et al
Oncotarget (2016) 7 (25), 38210-38223 DOI: 10.18632/oncotarget.9427
Snippet: Endogenous peroxidase activity was destroyed with 3% H2O2 in methanol for 30 min. After blocking nonspecific sites, tissues were incubated overnight at 4°C with anti-CD46 antibody (1:200, Origene, Rockville, MD, USA)
Showing 1-1 of 1 papers.
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