KIRREL2 Rabbit Polyclonal Antibody

CAT#: TA349102

Rabbit Polyclonal Anti-KIRREL2 Antibody

Product Images

Western blot analysis of KIRREL2 in 293 cell lysate with KIRREL2 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.

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  Immunohistochemistry of KIRREL2 in human pancreas tissue with KIRREL2 antibody at 5 ug/mL.

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  Immunofluorescence of KIRREL2 in human pancreas tissue with KIRREL2 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, IHC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: KIRREL2 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human KIRREL2.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: KIRREL2 antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 64, 70, 78 kDa; Observed: 70 kDa
• Gene Name: kin of IRRE like 2 (Drosophila)
• Database Link:
  NP_954649
  Entrez Gene 84063 Human
  UniProt ID Q6UWL6
• Background: KIRREL2, also known as nephrin-like 3, is a type I transmembrane protein belonging to the immunoglobulin superfamily of cell adhesion molecules (1). KIRREL2 consists of five extracellular Ig-like repeats, a transmembrane domain, several glycosylation sites and a cytoplasmic domain that has a stretch of nine conserved residues (1,2). KIRREL2 has been found to be expressed in beta cells of pancreatic islets and is involved in the regulation of both glomerular and neural development (3,4). Downregulation of KIRREL2 is implicated in several proteinuric diseases (4,5).
• Synonyms: HI95; SES2; SEST2