Mitofusin 2 (MFN2) Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | IF, IHC, WB |
|---|---|
| Recommended Dilution | WB: 1 - 2 ug/mL, IHC: 5 ug/mL, IF: 20 ug/mL |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | MFN2 antibody was raised against a 17 amino acid peptide near the center of human MFN2. The immunogen is located within amino acids 250 - 300 of MFN2. |
| Buffer | PBS containing 0.02% sodium azide. |
| Concentration | 1 mg/ml |
| Purification | MFN2 antibody is affinity chromatography purified via peptide column. |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | Predicted: 83 kDa; Observed: 90 kDa |
| Gene Name | mitofusin 2 |
| Database Link | |
| Background | Mitofusin 2 (MFN2) and the related protein MFN1 are mitochondrial membrane GTPase proteins that play a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes (1,2). MFN2 is ubiquitously expressed, and found in both the ER and outer mitochondrial membrane. MFN2 has two key domains: a coiled coil region that mediates MFN2 binding and a GTPase domain that likely plays a role in fusion (3,4). Both domains are essential for embryonic development and may play a role in the pathobiology of obesity. Overexpression of MFN2 causes mitochondrial dysfunction and cell death (5). |
| Synonyms | ARF-GEP100; ARFGEP100; BRAG2; GEP100 |
| Reference Data | |
| Protein Categories | Intracellular Proteins, Membrane Proteins, Nervous system: Neurodegenerative diseases |
| Protein Families | Transmembrane |
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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