PINK1 Rabbit Polyclonal Antibody

CAT#: TA349062

Rabbit Polyclonal Anti-PINK1 Antibody

Product Images

Western blot analysis of PINK1 in A431 cell lysate with PINK1 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1 - 2 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: PINK1 antibody was raised against a 16 amino acid peptide near the amino terminus of human PINK1.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: PINK1 antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 55 kDa; Observed: 53 kDa
• Gene Name: PTEN induced putative kinase 1
• Database Link:
  NP_115785
  Entrez Gene 68943 MouseEntrez Gene 298575 RatEntrez Gene 65018 Human
  UniProt ID Q9BXM7
• Background: The PTEN-induced putative kinase 1 (PINK1) is a serine/threonine protein kinase that localizes to mitochondria and is thought to protect cells from stress-induced mitochondrial dysfunction (reviewed in 1). PINK1 recruits the E3 ubiquitin ligase Parkin to mitochondria to initiate mitophagy, an autophagic process that clears damaged mitochondria within a cell (2). PINK1 is cleaved by the mitochondrial protease PARL (3). Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease (4).
• Synonyms: BRPK; PARK6

Reference Data

• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: Parkinson's disease