HMG1 (HMGB1) Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | ELISA, IF, IHC, WB |
|---|---|
| Recommended Dilution | WB: 1 µg/mL; IHC: 1-2 µg/mL; IF: 20 µg/mL. Antibody validated: Western Blot in human, mouse and rat samples; Immunohistochemistry in human, mouse, and rat samples; Immunofluorescence in human samples. All other applications and species not yet tested. |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | HMGB1 antibody was raised against a 19 amino acid peptide near the center of human HMGB1. |
| Specificity | HMGB1 antibody is human, mouse and rat reactive. |
| Buffer | PBS containing 0.02% sodium azide. |
| Concentration | 1 mg/ml |
| Purification | HMGB1 antibody is affinity chromatography purified via peptide column. |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | Predicted: 24 kDa; Observed: 24 kDa |
| Gene Name | high mobility group box 1 |
| Database Link | |
| Background | The high-mobility group box 1 (HMGB1) protein was originally identified as a highly conserved nuclear DNA-binding protein that participates in DNA replication, repair and transcriptional regulation of gene expression (1,2). However, HMGB1 has more recently emerged as an extracellularly released mediator of inflammation and repair responses in lipopolysaccharide (LPS)-induced endotoxemia and sepsis (3). HMGB1 has also been suggested to induce secretion of pro-inflammatory cytokines and chemokines by inducing NF-kB signaling downstream of Toll-like receptor (TLR) 2 and TLR4 activation (4). |
| Synonyms | HMG1; HMG3; SBP-1 |
| Reference Data | |
| Protein Categories | Chemokines, Cytokines, Intracellular Proteins, Secreated Proteins |
| Protein Families | Druggable Genome, Stem cell - Pluripotency, Transcription Factors |
| Protein Pathways | Base excision repair |
Reviews
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Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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