VAV3 Rabbit Polyclonal Antibody

CAT#: TA348443

Rabbit Polyclonal Anti-Phospho-VAV3(Tyr173) Antibody

Product Images

Western blot analysis on JK cell lysate using Phospho-VAV3 (Tyr173) Antibody.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500-1:2000
• Reactivities: Human, Mouse
• Modifications: Phospho-specific
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The immunogen for anti-Phospho-VAV3(Tyr173) Antibody: A synthesized peptide derived from human VAV3 around the phosphorylation site of Tyrosine 173
• Formulation: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20?. Stable for 12 months from date of receipt
• Concentration: lot specific
• Purification: Immunogen affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 100 kDa
• Gene Name: vav guanine nucleotide exchange factor 3
• Database Link:
  NP_006104
  Entrez Gene 57257 MouseEntrez Gene 10451 Human
  UniProt ID Q9UKW4
• Background: This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq]
• Synonyms: FLJ40431
• Note: Phospho-VAV3(Tyr173) Antibody detects endogenous levels of VAV3 only when phosphorylated at Tyrosine 173

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: B cell receptor signaling pathway, Chemokine signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, Focal adhesion, Leukocyte transendothelial migration, Natural killer cell mediated cytotoxicity, Regulation of actin cytoskeleton, T cell receptor signaling pathway