EP300 Rabbit Polyclonal Antibody

CAT#: TA348039

Rabbit Polyclonal Anti-P300/CBP Antibody

Product Images

Western blot analysis of P300/CBP expression in COLO205 cells

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500-1:2000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The immunogen for anti-P300/CBP Antibody: A synthesized peptide derived from human P300/CBP
• Formulation: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 ?.Stable for 12 months from date of receipt
• Concentration: lot specific
• Purification: Immunogen affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 300 kDa
• Gene Name: E1A binding protein p300
• Database Link:
  NP_001420
  Entrez Gene 328572 MouseEntrez Gene 170915 RatEntrez Gene 2033 Human
  UniProt ID Q09472
• Background: Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Also functions as acetyltransferase for nonhistone targets. Acetylates 'Lys-131' of ALX1 and acts as its coactivator in the presence of CREBBP.
• Synonyms: KAT3B; p300; RSTS2
• Note: P300/CBP Antibody detects endogenous levels of total P300/CBP

Reference Data

• Protein Families: Druggable Genome, Transcription Factors
• Protein Pathways: Adherens junction, Cell cycle, Huntington's disease, Jak-STAT signaling pathway, Long-term potentiation, Melanogenesis, Notch signaling pathway, Pathways in cancer, Prostate cancer, Renal cell carcinoma, TGF-beta signaling pathway, Wnt signaling pathway