NOTCH2 Rabbit Polyclonal Antibody
$380.00
4 Weeks*
Specifications
| Product Data | |
| Application | WB |
|---|---|
| Recommended Dilution | WB: 1:500-1:2000 |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | The immunogen for anti-NOTCH2 (Cleaved-Ala1734) Antibody: A synthesized peptide derived from human NOTCH2 (Cleaved-Ala1734) |
| Buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 ?.Stable for 12 months from date of receipt |
| Concentration | lot specific |
| Purification | Immunogen affinity purified |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | 110 kDa |
| Gene Name | notch 2 |
| Database Link | |
| Background | Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. |
| Synonyms | AGS2; HJCYS; hN2 |
| Note | NOTCH2 (Cleaved-Ala1734) Antibody detects endogenous levels of total NOTCH2 (Cleaved-Ala1734) |
| Reference Data | |
| Protein Categories | Endocrine and metabolic diseases, Growth Factors, Intracellular Proteins, Membrane Proteins |
| Protein Families | Druggable Genome, Transmembrane |
| Protein Pathways | Dorso-ventral axis formation, Notch signaling pathway |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Citations
Multivalent forms of the Notch ligand DLL-1 enhance antitumor T cell immunity in lung cancer and improve efficacy of EGFR targeted therapy
Biktasova, Dudimah, Uzhachenko et al
Cancer Res. (2015)
Biktasova, Dudimah, Uzhachenko et al
Cancer Res. (2015)
AI Summary: OriGene Technologies contributed to this study by providing the Notch2 antibody, which was used to detect Notch2 protein expression in experimental analyses.
Snippet: Piscataway, NJ). The following antibodies were used for detection: Notch1 (Cell Signaling, MA);Notch2 (Origene Technologies, Rockville, MD);Notch3 and DLL4 (Abcam, Cambridge, MA);Notch4 (Millipore, Page 9. 9 Billerica ... Cite SaveSaving
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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