FARP2 Rabbit Polyclonal Antibody
Rabbit Polyclonal Anti-FIR Antibody
Product Datasheet for 'TA347647'
|Recommend Dilution||WB: 1:500-1:2000|
|Immunogen||The immunogen for anti-FIR Antibody: A synthesized peptide derived from human FIR|
|Formulation||Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20?. Stable for 12 months from date of receipt|
|Purification||Immunogen affinity purified|
|Predicted Protein Size||119 kDa|
|Gene Name||FERM, ARH/RhoGEF and pleckstrin domain protein 2|
|Background||Rho-guanine nucleotide exchange factor that activates RAC1. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Interacts with PLXNA1. Interaction with PLXNA1 or PIP5K1C lowers its guanine nucleotide exchange activity. Dissociates from PLXNA1 when SEMA3A binds to the receptor.Interacts with PIP5K1C via its FERM domain. The interaction with PIP5K1C is enhanced by SEMA3A binding. 2 isoforms of the human protein are produced by alternative splicing.|
|Synonyms||FIR; FRG; PLEKHC3|
|Note||FIR Antibody detects endogenous levels of FIR|
|Protein Pathways||Adherens junction|
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.