SKP2 Rabbit Polyclonal Antibody

CAT#: TA347631

Rabbit Polyclonal Anti-SKP2/p45 Antibody

Product Images

Western blot analysis on 293 cell lysate using SKP2/p45 Antibody

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500-1:2000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The immunogen for anti-SKP2/p45 Antibody: A synthesized peptide derived from human SKP2/p45
• Formulation: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20?. Stable for 12 months from date of receipt
• Concentration: lot specific
• Purification: Immunogen affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 47 kDa
• Gene Name: S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
• Database Link:
  NP_005974
  Entrez Gene 6502 Human
  UniProt ID Q13309
• Background: SKP2 an F-box protein of the SCF (SKP1-CUL1-F- box protein) E3 ubiquitin ligase system. The F-box component of the SCF complex is responsible for recognizing different substrates for ubiquitination. The SCF E3 complex mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Three alternatively-spliced isoforms have been described.
• Synonyms: FBL1; FBXL1; FLB1; p45
• Note: SKP2/p45 Antibody detects endogenous levels of SKP2/p45

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Acute myeloid leukemia, Apoptosis, Cell cycle, Oocyte meiosis, p53 signaling pathway, Pathways in cancer, Progesterone-mediated oocyte maturation, Small cell lung cancer, Ubiquitin mediated proteolysis