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PFKFB2 Rabbit Polyclonal Antibody

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SKU
TA347548
Rabbit Polyclonal Anti-PFKFB2 Antibody
Size:
100 ug
Conjugation:
Unconjugated
  $380.00
2 Weeks*
Bulk/Customize

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LY422707 Transient overexpression lysate of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (PFKFB2), transcript variant 2 (as WB positive control) 100 ug
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View other "PFKFB2 or NM_006212" antibodies

Specifications
Specifications
Product Data
Application WB
Recommended Dilution WB: 1:500-1:3000
Reactivity Human, Mouse
Antibody Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen The immunogen for anti-PFKFB2 Antibody: A synthesized peptide derived from human PFKFB2
Buffer Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20?. Stable for 12 months from date of receipt
Concentration lot specific
Purification Affinity-chromatography
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Blue Ice
Predicted Protein Size 58 kDa
Gene Name 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
Database Link
Background PFKFB2 a bifunctional heterodimeric enzyme involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. Regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle.
Synonyms FBPase-2; PFK-2
Note PFKFB2 antibody detects endogenous levels of total PFKFB2
Reference Data
Protein Categories Intracellular Proteins
Protein Families Druggable Genome
Protein Pathways Fructose and mannose metabolism
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Documents
Resources

file-alt Citations

GC–MS metabolic profiling reveals fructose-2,6-bisphosphate regulates branched chain amino acid metabolism in the heart during fasting
Batushansky, Matsuzaki, Newhardt et al
Metabolomics (2019) 15 (2) DOI: 10.1007/s11306-019-1478-5
AI Summary: OriGene’s PFK-2 antibody (catalog #TA347548) was used in this study to detect PFK-2 protein levels, enabling the authors to investigate the regulation of branched chain amino acid metabolism in the heart during fasting.
Snippet: PFK-2 (Origene #TA347548, 1:3000 dilution) or phospho-Ser483 PFK-2 (Cell Signaling Technologies #13,064;1:2000 dilution) antibodies were added overnight at 4 °C, subsequently washed the following day, and the secondary antibody (IRDye 800CW, LI-COR;
WB
GC-MS metabolic profiling reveals fructose-2,6-bisphosphate regulates branched chain amino acid metabolism in the heart during fasting
Batushansky, Matsuzaki, Newhardt et al
Metabolomics (2019) 15 (2), 18 DOI: 10.1007/s11306-019-1478-5
AI Summary: OriGene’s PFK-2 antibody (OriGene #TA347548) was used for protein detection in this study, enabling the authors to assess PFK-2 levels and investigate its role in regulating cardiac metabolism during fasting.
Snippet: PFK-2 (Origene #TA347548, 1:3000 dilution) or phospho-Ser483 PFK-2 (Cell Signaling Technologies #13,064;1:2000 dilution) antibodies were added overnight at 4 °C, subsequently washed the following day, and the secondary antibody (IRDye 800CW, LI-COR;
WB
Cardiac Insulin Signaling Regulates Glycolysis Through Phosphofructokinase 2 Content and Activity
Bockus, Matsuzaki, Vadvalkar et al
J Am Heart Assoc (2017) 6 (12) DOI: 10.1161/JAHA.117.007159
AI Summary: OriGene's anti-PFKFB2 antibody was used in this study to detect and quantify PFK-2 protein levels, enabling the researchers to assess how insulin signaling affects PFK-2 content and cardiac glycolysis.
Snippet: The exceptions were antibodies against PFKFB2 (OriGene, Rockville, MD), p62 (Abcam, Cambridge, UK), and horseradish peroxidase – conju- gated actin (Santa Cruz Biotechnology, Dallas, TX)
WB
Showing 1-3 of 3 papers.
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