APLF Rabbit Polyclonal Antibody

SKU TA347336

Rabbit Polyclonal Anti-APLF Antibody

Product Data

• Application: WB
• Recommended Dilution: WB: 1:500-1:3000
• Reactivity: Human, Mouse
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The immunogen for anti-APLF Antibody: A synthesized peptide derived from human APLF
• Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20?. Stable for 12 months from date of receipt
• Concentration: lot specific
• Purification: Affinity-chromatography
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Predicted Protein Size: 57 kDa
• Gene Name: aprataxin and PNKP like factor
• Database Link:
  NP_775816
  Q8IW19
• Background: APLF Nuclease involved in single-strand and double-strand DNA break repair. Recruited to sites of DNA damage through interaction with poly(ADP-ribose), a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions. Displays apurinic- apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro. Also able to introduce nicks at hydroxyuracil and other types of pyrimidine base damage. Belongs to the APLF family. Interacts with LIG4, PARP1, XRCC1, XRCC4 and XRCC5.
• Synonyms: APFL; C2orf13; PALF; Xip1; ZCCHH1
• Note: APLF antibody detects endogenous levels of total APLF

Reference Data